Reactome | Defective SLC17A8 does not exchange cytosolic L-Glu for synaptic vesicle H+

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Defective SLC17A8 does not exchange cytosolic L-Glu for synaptic vesicle H+ Show undefined attributes

authored	[InstanceEdit:5624287] Jassal, Bijay, 2014-09-22
catalystActivity	[CatalystActivity:9631755] L-glutamate transmembrane transporter activity of SLC17A8 A211V [synaptic vesicle membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:20600] synaptic vesicle [Compartment:201753] synaptic vesicle membrane
created	[InstanceEdit:5624287] Jassal, Bijay, 2014-09-22
crossReference	[DatabaseIdentifier:12021014] Mondo:0019587
dbId	5624256
disease	[Disease:5624283] autosomal dominant nonsyndromic deafness
displayName	Defective SLC17A8 does not exchange cytosolic L-Glu for synaptic vesicle H+
edited	[InstanceEdit:5624287] Jassal, Bijay, 2014-09-22
entityFunctionalStatus	[EntityFunctionalStatus:5624245] loss_of_function of SLC17A8 A211V [synaptic vesicle membrane]
eventOf	[Pathway:R-HSA-5619076] Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) - Homo sapiens
input	[SimpleEntity:R-ALL-428548] H+ [synaptic vesicle] [SimpleEntity:R-ALL-29404] L-Glu [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5624263] Impairment of SLC17A8 encoding vesicular glutamate transporter-3, VGLUT3, underlies nonsyndromic deafness DFNA25 and inner hair cell dysfunction in null mice
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Defective SLC17A8 does not exchange cytosolic L-Glu for synaptic vesicle H+
normalReaction	[Reaction:R-HSA-428052] SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6789776] Broer, Stefan, 2015-08-04
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5624256
summation	[Summation:5624267] There are two classes of glutamate transporters; the excitat...
updateTrackers	[UpdateTracker:9777981] Update Tracker - [FailedReaction:5624256] Defective SLC17A8 does not exchange cytosolic L-Glu for synaptic vesicle H+ - v68:[addCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9777981] Update Tracker - [FailedReaction:5624256] Defective SLC17A8 does not exchange cytosolic L-Glu for synaptic vesicle H+ - v68:[addCatalystActivity]
(hasEvent)	[Pathway:R-HSA-5619076] Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25)

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