Reactome | Defective SLC16A1 does not cotransport monocarboxylates, H+ from extracellular region to cytosol

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Defective SLC16A1 does not cotransport monocarboxylates, H+ from extracellular region to cytosol Show undefined attributes

authored	[InstanceEdit:5624215] Jassal, Bijay, 2014-09-22
catalystActivity	[CatalystActivity:9638134] monocarboxylic acid transmembrane transporter activity of SLC16A1 mutants:BSG [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5624215] Jassal, Bijay, 2014-09-22
crossReference	[DatabaseIdentifier:12020859] Mondo:0019052
dbId	5624211
disease	[Disease:5602847] inherited metabolic disorder
displayName	Defective SLC16A1 does not cotransport monocarboxylates, H+ from extracellular region to cytosol
edited	[InstanceEdit:5624215] Jassal, Bijay, 2014-09-22
entityFunctionalStatus	[EntityFunctionalStatus:5624209] loss_of_function of SLC16A1 mutants:BSG [plasma membrane]
eventOf	[Pathway:R-HSA-5619070] Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) - Homo sapiens
input	[SimpleEntity:R-ALL-351626] H+ [extracellular region] [DefinedSet:R-ALL-433683] MCT substrates [extracellular region]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:373894] Mutations in MCT1 cDNA in patients with symptomatic deficiency in lactate transport
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Defective SLC16A1 does not cotransport monocarboxylates, H+ from extracellular region to cytosol
normalReaction	[Reaction:R-HSA-9645220] SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6789776] Broer, Stefan, 2015-08-04
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5624211
summation	[Summation:5624201] Four members of the SLC16A gene family encode classical mono...
updateTrackers	[UpdateTracker:9778349] Update Tracker - [FailedReaction:5624211] Defective SLC16A1 does not cotransport monocarboxylates, H+ from extracellular region to cytosol - v68:[addCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9778349] Update Tracker - [FailedReaction:5624211] Defective SLC16A1 does not cotransport monocarboxylates, H+ from extracellular region to cytosol - v68:[addCatalystActivity]
(hasEvent)	[Pathway:R-HSA-5619070] Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)

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