Reactome | IRAK4 deficiency (TLR2/4)

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IRAK4 deficiency (TLR2/4) Show undefined attributes

authored	[InstanceEdit:5545427] Shamovsky, V, 2014-05-21
created	[InstanceEdit:5603042] Shamovsky, Veronica, 2014-06-26
crossReference	[DatabaseIdentifier:12819549] BioModels Database:BIOMD0000000338 [DatabaseIdentifier:12021025] Mondo:0003778 [DatabaseIdentifier:12819551] BioModels Database:BIOMD0000000340 [DatabaseIdentifier:12819559] BioModels Database:BIOMD0000000339 [DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477
dbId	5603041
disease	[Disease:5228860] primary immunodeficiency disease
displayName	IRAK4 deficiency (TLR2/4)
edited	[InstanceEdit:5673719] Shamovsky, Veronica, 2015-02-09
eventOf	[Pathway:R-HSA-5602358] Diseases associated with the TLR signaling cascade - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[FailedReaction:R-HSA-5602353] Defective IRAK4 does not bind MyD88:MAL:BTK:activated TLR2/4 - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2020-09-24
literatureReference	[LiteratureReference:5602589] Functional assessment of the mutational effects of human IRAK4 and MyD88 genes [LiteratureReference:5602465] Pyogenic bacterial infections in humans with IRAK-4 deficiency [LiteratureReference:5602389] Pyogenic bacterial infections in humans with MyD88 deficiency [LiteratureReference:5602701] Primary immunodeficiency to pneumococcal infection due to a defect in Toll-like receptor signaling
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	IRAK4 deficiency (TLR2/4)
normalPathway	[Pathway:R-HSA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane
previousReviewStatus	[ReviewStatus:9821384] two stars
relatedSpecies	[Species:181384] Chlamydia trachomatis [Species:180800] Neisseria meningitidis serogroup B
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5621924] D'Eustachio, Peter, 2014-09-06 [InstanceEdit:5675062] McDonald, Douglas R, 2015-02-15 [InstanceEdit:9919279] Matthews, Lisa, 2024-08-20
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5603041
summation	[Summation:5607978] Interleukin-1 receptor-associated kinase 4 (IRAK4) is a seri...
updateTrackers	[UpdateTracker:9780040] Update Tracker - [Pathway:5603041] IRAK4 deficiency (TLR2/4) - v64:[updateContainedRLE] [UpdateTracker:9776665] Update Tracker - [Pathway:5603041] IRAK4 deficiency (TLR2/4) - v74:[updateContainedRLE] [UpdateTracker:9778866] Update Tracker - [Pathway:5603041] IRAK4 deficiency (TLR2/4) - v67:[updateContainedRLE] [UpdateTracker:9919396] Update Tracker - [Pathway:5603041] IRAK4 deficiency (TLR2/4) - v90:[addHasEvent, modifyText]

Referrals

(updatedInstance)

[UpdateTracker:9780040] Update Tracker - [Pathway:5603041] IRAK4 deficiency (TLR2/4) - v64:[updateContainedRLE]
[UpdateTracker:9776665] Update Tracker - [Pathway:5603041] IRAK4 deficiency (TLR2/4) - v74:[updateContainedRLE]
[UpdateTracker:9778866] Update Tracker - [Pathway:5603041] IRAK4 deficiency (TLR2/4) - v67:[updateContainedRLE]
[UpdateTracker:9919396] Update Tracker - [Pathway:5603041] IRAK4 deficiency (TLR2/4) - v90:[addHasEvent, modifyText]

(hasEvent)

[Pathway:R-HSA-5602358] Diseases associated with the TLR signaling cascade

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