Reactome | IRAK4 deficiency (TLR5)

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IRAK4 deficiency (TLR5) Show undefined attributes

authored	[InstanceEdit:5545427] Shamovsky, V, 2014-05-21
created	[InstanceEdit:5603042] Shamovsky, Veronica, 2014-06-26
dbId	5603037
disease	[Disease:5228860] primary immunodeficiency disease
displayName	IRAK4 deficiency (TLR5)
edited	[InstanceEdit:5673719] Shamovsky, Veronica, 2015-02-09
eventOf	[Pathway:R-HSA-5602358] Diseases associated with the TLR signaling cascade - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[FailedReaction:R-HSA-5602472] Defective IRAK4 does not form a complex with MyD88 within the TLR5 complex - Homo sapiens [FailedReaction:R-HSA-5602603] IRAK4 deficiency blocks formation of the MyD88-IRAK4 Myddosome in the TLR5 pathway - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5602589] Functional assessment of the mutational effects of human IRAK4 and MyD88 genes [LiteratureReference:5602465] Pyogenic bacterial infections in humans with IRAK-4 deficiency [LiteratureReference:5602585] Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	IRAK4 deficiency (TLR5)
normalPathway	[Pathway:R-HSA-975871] MyD88 cascade initiated on plasma membrane
relatedSpecies	[Species:159879] Escherichia coli
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5621924] D'Eustachio, Peter, 2014-09-06 [InstanceEdit:5675062] McDonald, Douglas R, 2015-02-15
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5603037
summation	[Summation:5607963] Toll like receptor 5 (TLR5) specifically recognizes bacteria...

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(hasEvent)

[Pathway:R-HSA-5602358] Diseases associated with the TLR signaling cascade