Reactome | SERPINA5 binds activated protein C

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SERPINA5 binds activated protein C Show undefined attributes

authored	[InstanceEdit:5607780] Jupe, Steve, 2014-07-14
category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:5591039] Jupe, Steve, 2014-06-11
dbId	5591086
displayName	SERPINA5 binds activated protein C
edited	[InstanceEdit:5627264] Jupe, Steve, 2014-07-28
eventOf	[Pathway:R-HSA-9769739] Regulation of clotting cascade - Homo sapiens
input	[Complex:R-HSA-141050] Activated protein C [extracellular region] [EntityWithAccessionedSequence:R-HSA-5591085] SERPINA5 [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5607038] Mechanism of inhibition of activated protein C by protein C inhibitor
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	SERPINA5 binds activated protein C
orthologousEvent	[Reaction:R-GGA-5591086] SERPINA5 binds activated protein C - Gallus gallus [Reaction:R-XTR-5591086] SERPINA5 binds activated protein C - Xenopus tropicalis [Reaction:R-DRE-5591086] SERPINA5 binds activated protein C - Danio rerio [Reaction:R-SSC-5591086] SERPINA5 binds activated protein C - Sus scrofa [Reaction:R-BTA-5591086] SERPINA5 binds activated protein C - Bos taurus [Reaction:R-CFA-5591086] SERPINA5 binds activated protein C - Canis familiaris [Reaction:R-RNO-5591086] SERPINA5 binds activated protein C - Rattus norvegicus [Reaction:R-MMU-5591086] SERPINA5 binds activated protein C - Mus musculus
output	[Complex:R-HSA-5607007] SERPINA5:Activated protein C [extracellular region]
regulatedBy	[PositiveRegulation:R-HSA-5607096] Positive regulation by 'GAG [plasma membrane]'
regulationReference	[RegulationReference:9642046] Positive regulation by 'GAG [plasma membrane]' The N-terminal acidic domain of heparin cofactor II mediates the inhibition of alpha-thrombin in the presence of glycosaminoglycans
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5627265] Mumford, Andrew, 2014-09-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5591086
summation	[Summation:5591026] SERPINA5, also called Plasma serine protease inhibitor or Pr...
systematicName	SERPINA5 binds Activated protein C forming SERPINA5:Activated protein C
updateTrackers	[UpdateTracker:9939636] Update Tracker - [Reaction:5591086] SERPINA5 binds activated protein C - v92:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9939636] Update Tracker - [Reaction:5591086] SERPINA5 binds activated protein C - v92:[modifyText]
(hasEvent)	[Pathway:R-HSA-9769739] Regulation of clotting cascade

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