Reactome | Importin-8 binds AGO2:miRNA

Schema > Reaction > Entries

Importin-8 binds AGO2:miRNA Show undefined attributes

authored	[InstanceEdit:5578729] May, Bruce, 2014-05-30
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5578738] May, Bruce, 2014-05-31
dbId	5578712
displayName	Importin-8 binds AGO2:miRNA
edited	[InstanceEdit:5578729] May, Bruce, 2014-05-30
eventOf	[Pathway:R-HSA-5578749] Transcriptional regulation by small RNAs - Homo sapiens
followingEvent	[Reaction:R-HSA-5578744] Importin-8 imports AGO2:miRNA into the nucleus - Homo sapiens
input	[Complex:R-HSA-2106621] AGO2:miRNA [cytosol] [EntityWithAccessionedSequence:R-HSA-5578740] IPO8 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5578698] Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs [LiteratureReference:5578719] Importin 8 regulates the transport of mature microRNAs into the cell nucleus [LiteratureReference:5578752] Direct evidence of nuclear Argonaute distribution during transcriptional silencing links the actin cytoskeleton to nuclear RNAi machinery in human cells [LiteratureReference:5578705] MicroRNA-directed transcriptional gene silencing in mammalian cells [LiteratureReference:5579131] RNAi factors are present and active in human cell nuclei
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	Importin-8 binds AGO2:miRNA
orthologousEvent	[Reaction:R-SSC-5578712] Importin-8 binds AGO2:miRNA - Sus scrofa [Reaction:R-SPO-5578712] Importin-8 binds AGO2:miRNA - Schizosaccharomyces pombe [Reaction:R-DME-5578712] Importin-8 binds AGO2:miRNA - Drosophila melanogaster [Reaction:R-GGA-5578712] Importin-8 binds AGO2:miRNA - Gallus gallus [Reaction:R-BTA-5578712] Importin-8 binds AGO2:miRNA - Bos taurus [Reaction:R-CFA-5578712] Importin-8 binds AGO2:miRNA - Canis familiaris [Reaction:R-RNO-5578712] Importin-8 binds AGO2:miRNA - Rattus norvegicus [Reaction:R-MMU-5578712] Importin-8 binds AGO2:miRNA - Mus musculus
output	[Complex:R-HSA-5578743] IPO8:AGO2:miRNA [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-210805] Removal of miRNA passenger strand - Homo sapiens
releaseDate	2014-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5619520] Li, Long-Cheng, 2014-08-25 [InstanceEdit:5621991] Stroynowska-Czerwinska, Anna, 2014-09-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5578712
summation	[Summation:5578979] Importin-8 (IPO8, IMP8, RANBP8) binds AGO2:miRNA complexes i...

Referrals

(hasEvent)	[Pathway:R-HSA-5578749] Transcriptional regulation by small RNAs
(precedingEvent)	[Reaction:R-HSA-5578744] Importin-8 imports AGO2:miRNA into the nucleus