Importin-8 binds AGO2:miRNA

Stable Identifier
R-HSA-5578712
Type
Reaction [binding]
Species
Homo sapiens
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Importin-8 (IPO8, IMP8, RANBP8) binds AGO2:miRNA complexes in the cytosol and participates in the importation of AGO2:miRNA complexes into the nucleus (Weinmann et al. 2009, Wei et al. 2014). IPO8 is also required for recruitment of AGO2:miRNA complexes to many target mRNAs in the cytosol and their efficient silencing (Weinmann et al. 2009). Moreover, other Argonautes (AGO1, AGO3, AGO4) are also observed in the nucleus (Kim et al. 2008, Weinmann et al. 2009, Ahlenstiel et al. 2012, Gagnon et al. 2014) and may be imported by the same mechanism.

Literature References
PubMed ID Title Journal Year
24388755 RNAi factors are present and active in human cell nuclei

Gagnon, KT, Li, L, Chu, Y, Janowski, BA, Corey, DR

Cell Rep 2014
19167051 Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs

Weinmann, L, Höck, J, Ivacevic, T, Ohrt, T, Mütze, J, Schwille, P, Kremmer, E, Benes, V, Urlaub, H, Meister, G

Cell 2009
24596094 Importin 8 regulates the transport of mature microRNAs into the cell nucleus

Wei, Y, Li, L, Wang, D, Zhang, CY, Zen, K

J. Biol. Chem. 2014
22064859 Direct evidence of nuclear Argonaute distribution during transcriptional silencing links the actin cytoskeleton to nuclear RNAi machinery in human cells

Ahlenstiel, CL, Lim, HG, Cooper, DA, Ishida, T, Kelleher, AD, Suzuki, K

Nucleic Acids Res. 2012
18852463 MicroRNA-directed transcriptional gene silencing in mammalian cells

Kim, DH, Saetrom, P, Snøve, O, Rossi, JJ

Proc. Natl. Acad. Sci. U.S.A. 2008
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