Reactome | Importin-8 binds AGO2:miRNA

Importin-8 binds AGO2:miRNA

Stable Identifier

R-HSA-5578712

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Importin-8 (IPO8, IMP8, RANBP8) binds AGO2:miRNA complexes in the cytosol and participates in the importation of AGO2:miRNA complexes into the nucleus (Weinmann et al. 2009, Wei et al. 2014). IPO8 is also required for recruitment of AGO2:miRNA complexes to many target mRNAs in the cytosol and their efficient silencing (Weinmann et al. 2009). Moreover, other Argonautes (AGO1, AGO3, AGO4) are also observed in the nucleus (Kim et al. 2008, Weinmann et al. 2009, Ahlenstiel et al. 2012, Gagnon et al. 2014) and may be imported by the same mechanism.

Literature References

PubMed ID	Title	Journal	Year
19167051	Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs Weinmann, L, Höck, J, Ivacevic, T, Ohrt, T, Mütze, J, Schwille, P, Kremmer, E, Benes, V, Urlaub, H, Meister, G	Cell	2009
24388755	RNAi factors are present and active in human cell nuclei Gagnon, KT, Li, L, Chu, Y, Janowski, BA, Corey, DR	Cell Rep	2014
24596094	Importin 8 regulates the transport of mature microRNAs into the cell nucleus Wei, Y, Li, L, Wang, D, Zhang, CY, Zen, K	J. Biol. Chem.	2014
22064859	Direct evidence of nuclear Argonaute distribution during transcriptional silencing links the actin cytoskeleton to nuclear RNAi machinery in human cells Ahlenstiel, CL, Lim, HG, Cooper, DA, Ishida, T, Kelleher, AD, Suzuki, K	Nucleic Acids Res.	2012
18852463	MicroRNA-directed transcriptional gene silencing in mammalian cells Kim, DH, Saetrom, P, Snøve, O, Rossi, JJ	Proc. Natl. Acad. Sci. U.S.A.	2008