Reactome | Positive regulation by 'p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol]'

Schema > PositiveRegulation > Entries

created	[InstanceEdit:5357856] Shamovsky, V, 2014-03-26
dbId	5357877
displayName	Positive regulation by 'p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol]'
modified	[InstanceEdit:9733355] Wu, Guanming, 2021-06-04
regulatedEntity	[Reaction:R-HSA-9701055] TRPA1 tetramer transports Ca2+ from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-3295579] TRPs transport extracellular Ca2+ to cytosol - Homo sapiens [Reaction:R-HSA-9701141] TRPV1 transports Ca2+ from extracellular region to cytosol - Homo sapiens
regulator	[Complex:R-HSA-5357794] p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol]
schemaClass	PositiveRegulation
stId	R-HSA-5357877

(regulatedBy)	[Reaction:R-HSA-9701055] TRPA1 tetramer transports Ca2+ from extracellular region to cytosol [Reaction:R-HSA-3295579] TRPs transport extracellular Ca2+ to cytosol [Reaction:R-HSA-9701141] TRPV1 transports Ca2+ from extracellular region to cytosol
(regulation)	[RegulationReference:9642552] Positive regulation by 'p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol]' Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

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