Reactome | PMS2 [nucleoplasm]

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PMS2 [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-5357522] MLH1:PMS2 [nucleoplasm] - Homo sapiens
consumedByEvent	[FailedReaction:R-HSA-5545484] MLH1 variants-defective DNA mismatch repair - Homo sapiens [Reaction:R-HSA-5444523] Formation of MSH1:PMS2 Complex - Homo sapiens
created	[InstanceEdit:5357515] May, B, 2014-03-22
dbId	5357527
displayName	PMS2 [nucleoplasm]
endCoordinate	862
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-5357527] PMS2 [nucleoplasm] - Mus musculus [EntityWithAccessionedSequence:R-RNO-5357527] Pms2 [nucleoplasm] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-5357527] PMS2 [nucleoplasm] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-5357527] PMS2 [nucleoplasm] - Bos taurus [EntityWithAccessionedSequence:R-SSC-5357527] PMS2 [nucleoplasm] - Sus scrofa [GenomeEncodedEntity:R-DRE-5357527] Ghost homologue of PMS2 [nucleoplasm] - Danio rerio [EntityWithAccessionedSequence:R-GGA-5357527] PMS2 [nucleoplasm] - Gallus gallus [EntityWithAccessionedSequence:R-DME-5357527] Pms2 [nucleoplasm] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-5357527] pms-2 [nucleoplasm] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-DDI-5357527] pms1 [nucleoplasm] - Dictyostelium discoideum [EntityWithAccessionedSequence:R-SPO-5357527] pms1 [nucleoplasm] - Schizosaccharomyces pombe [EntityWithAccessionedSequence:R-SCE-5357527] PMS1 [nucleoplasm] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-PFA-5357527] PMS2 [nucleoplasm] - Plasmodium falciparum
maxDepth	1
name	PMS2 Mismatch repair endonuclease PMS2 ecNumber3.1.-.-/ecNumber PMS2_HUMAN
producedByEvent	[BlackBoxEvent:R-HSA-6806405] TP53 stimulates PMS2 expression - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:P54278] UniProt:P54278 PMS2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-5357527
startCoordinate	1

Referrals

(input)	[FailedReaction:R-HSA-5545484] MLH1 variants-defective DNA mismatch repair [Reaction:R-HSA-5444523] Formation of MSH1:PMS2 Complex
(normalEntity)	[EntityFunctionalStatus:5632956] loss_of_function of PMS2 Variants [nucleoplasm]
(activeUnit)	[CatalystActivity:5358530] endonuclease activity of MLH1:PMS2:MSH2:MSH3:ATP:PCNA:DNA containing IDL of 2 bases or more [nucleoplasm] [CatalystActivity:5358509] endonuclease activity of MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm]
(output)	[BlackBoxEvent:R-HSA-6806405] TP53 stimulates PMS2 expression
(hasComponent)	[Complex:R-HSA-5357522] MLH1:PMS2 [nucleoplasm]

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