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Schema
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Reaction
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Entries
PAK1-3 phosphorylates VE-cadherin
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authored
[InstanceEdit:4420157] Garapati, P V, 2013-08-30
catalystActivity
[CatalystActivity:5357431] protein serine/threonine kinase activity of p-S,T-PAK1,2,3 [cytosol]
catalystActivityReference
[CatalystActivityReference:9643726] protein serine/threonine kinase activity of p-S,T-PAK1,2,3 [cytosol] VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin
category
transition
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created
[InstanceEdit:5357434] Garapati, P V, 2014-03-21
dbId
5357477
displayName
PAK1-3 phosphorylates VE-cadherin
edited
[InstanceEdit:4420157] Garapati, P V, 2013-08-30
eventOf
[Pathway:R-HSA-5218920] VEGFR2 mediated vascular permeability - Homo sapiens
input
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[Complex:R-HSA-5357454] VE-cadherin-Catenin complex [plasma membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5357489] VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin
maxDepth
1
modified
[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name
PAK1-3 phosphorylates VE-cadherin
orthologousEvent
[Reaction:R-CEL-5357477] PAK1-3 phosphorylates VE-cadherin - Caenorhabditis elegans
[Reaction:R-DME-5357477] PAK1-3 phosphorylates VE-cadherin - Drosophila melanogaster
[Reaction:R-GGA-5357477] PAK1-3 phosphorylates VE-cadherin - Gallus gallus
[Reaction:R-XTR-5357477] PAK1-3 phosphorylates VE-cadherin - Xenopus tropicalis
[Reaction:R-DRE-5357477] PAK1-3 phosphorylates VE-cadherin - Danio rerio
[Reaction:R-SSC-5357477] PAK1-3 phosphorylates VE-cadherin - Sus scrofa
[Reaction:R-BTA-5357477] PAK1-3 phosphorylates VE-cadherin - Bos taurus
[Reaction:R-CFA-5357477] PAK1-3 phosphorylates VE-cadherin - Canis familiaris
[Reaction:R-RNO-5357477] PAK1-3 phosphorylates VE-cadherin - Rattus norvegicus
[Reaction:R-MMU-5357477] PAK1-3 phosphorylates VE-cadherin - Mus musculus
output
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[Complex:R-HSA-5357459] p-S665-VE-cadherin-Catenin complex [plasma membrane]
precedingEvent
[Reaction:R-HSA-5357472] PAK1-3 autophosphorylates - Homo sapiens
releaseDate
2014-06-10
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5432673] Welsh, Michael, Berger, Philipp, Ballmer-Hofer, Kurt, 2014-05-12
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5357477
summation
[Summation:5357439] Activated PAK then phosphorylates a serene residue (S665) wi...
Referrals
(hasEvent)
[Pathway:R-HSA-5218920] VEGFR2 mediated vascular permeability
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