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Schema
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misspliced mutants of LRP5 support enhanced beta-catenin-dependent signaling
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authored
[InstanceEdit:5334061] Rothfels, K, 2014-02-21
category
transition
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:5339710] Rothfels, K, 2014-03-07
crossReference
[DatabaseIdentifier:12020836] Mondo:0012004
dbId
5339711
disease
[Disease:1500689] cancer
[Disease:1500576] breast cancer
[Disease:5339671] parathyroid carcinoma
displayName
misspliced mutants of LRP5 support enhanced beta-catenin-dependent signaling
edited
[InstanceEdit:5358774] Matthews, Lisa, 2014-04-03
entityFunctionalStatus
[EntityFunctionalStatus:5339705] loss_of_function of LRP5 del666-809 [plasma membrane]
eventOf
[Pathway:R-HSA-5339717] Signaling by LRP5 mutants - Homo sapiens
input
[CandidateSet:R-HSA-3769325] DKK [extracellular region]
[CandidateSet:R-HSA-3769333] KRM1/2 [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-5339694] LRP5 D666_L809del [plasma membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:5340162] Accumulation of nonphosphorylated beta-catenin and c-myc in primary and uremic secondary hyperparathyroid tumors
[LiteratureReference:5339673] An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signaling
[LiteratureReference:5339692] The internally truncated LRP5 receptor presents a therapeutic target in breast cancer
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
misspliced mutants of LRP5 support enhanced beta-catenin-dependent signaling
normalReaction
[Reaction:R-HSA-3769401] DKK and KRM bind LRP5/6
releaseDate
2014-06-10
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5433076] Salahshor, S, 2014-05-12
[InstanceEdit:5545509] Woodgett, Jim, 2014-05-21
schemaClass
FailedReaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5339711
summation
[Summation:5340161] Frequent expression of an internally deleted LRP5 has been i...
Referrals
(hasEvent)
[Pathway:R-HSA-5339717] Signaling by LRP5 mutants
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