Reactome | botG HC:LC binds SYT1 and GT1b on the target cell surface

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botG HC:LC binds SYT1 and GT1b on the target cell surface Show undefined attributes

authored	[InstanceEdit:194836] Krupa, S, Gopinathrao, G, 2006-06-15 10:36:11
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5250954] D'Eustachio, Peter, 2014-01-31
crossReference	[DatabaseIdentifier:12020820] Mondo:0005498
dbId	5250986
deleted	[Deleted:5251022] Deletion of instance: 181359
disease	[Disease:3632909] botulism
displayName	botG HC:LC binds SYT1 and GT1b on the target cell surface
eventOf	[Pathway:R-HSA-5250989] Toxicity of botulinum toxin type G (botG) - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-5250979] botG:SYT1:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane - Homo sapiens
input	[Complex:R-CBO-5250691] botG HC:LC dimer [extracellular region] [SimpleEntity:R-ALL-5244403] GT1b [plasma membrane] [EntityWithAccessionedSequence:R-HSA-168786] SYT1 [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5250969] Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins [LiteratureReference:5250974] Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	botG HC:LC binds SYT1 and GT1b on the target cell surface
output	[Complex:R-HSA-5250975] botG:SYT1:GT1b [plasma membrane]
relatedSpecies	[Species:168825] Clostridium botulinum
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:201311] Ichtchenko, K, 2007-08-03 18:17:25 [InstanceEdit:5643756] Thirunavukkarasu, Nagarajan, Sharma, Shashi, 2014-11-17
revised	[InstanceEdit:5263589] D'Eustachio, Peter, 2014-02-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5250986
summation	[Summation:5263576] The botulinum toxin type G disulfide-bonded heavy chain - li...
updateTrackers	[UpdateTracker:9776548] Update Tracker - [Reaction:5250986] botG HC:LC binds SYT1 and GT1b on the target cell surface - v75:[modifyText] [UpdateTracker:9786223] Update Tracker - [Reaction:5250986] botG HC:LC binds SYT1 and GT1b on the target cell surface - v50:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776548] Update Tracker - [Reaction:5250986] botG HC:LC binds SYT1 and GT1b on the target cell surface - v75:[modifyText] [UpdateTracker:9786223] Update Tracker - [Reaction:5250986] botG HC:LC binds SYT1 and GT1b on the target cell surface - v50:[modifyText]
(replacementInstances)	[Deleted:5251022] Deletion of instance: 181359
(hasEvent)	[Pathway:R-HSA-5250989] Toxicity of botulinum toxin type G (botG)
(precedingEvent)	[BlackBoxEvent:R-HSA-5250979] botG:SYT1:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane

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