botG HC:LC binds SYT1 and GT1b on the target cell surface

Stable Identifier
R-HSA-5250986
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Clostridium botulinum
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The botulinum toxin type G disulfide-bonded heavy chain - light chain heterodimer ("dichain") (botG HC:LC) binds ganglioside GT1b and synaptotagmin-1 (SYT1) on the plasma membrane of a human target cell. In vivo, this process specifically targets synapses at neuromuscular junctions, where toxin association with ganglioside may position it to bind efficiently to SYT1 when that protein is exposed at the cell surface by exocytosis (Peng et al. 2012; Willjes et al. 2013).

Literature References
PubMed ID Title Journal Year
22454523 Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins

Peng, L, Berntsson, RP, Tepp, WH, Pitkin, RM, Johnson, EA, Stenmark, P, Dong, M

J. Cell. Sci. 2012
23647335 Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity

Willjes, G, Mahrhold, S, Strotmeier, J, Eichner, T, Rummel, A, Binz, T

Biochemistry 2013
Participants
Participates
Disease
Name Identifier Synonyms
botulism DOID:11976 Botulism (disorder), Intoxication with Clostridium botulinum toxin, Botulism, Infection due to clostridium botulinum, Botulism, Foodborne botulism, botulism, Botulism, Botulism, Botulism, Food poisoning due to Clostridium botulinum, Botulism poisoning
Authored
Reviewed
Created
Cite Us!