botG HC:LC binds SYT1 and GT1b on the target cell surface

Stable Identifier
R-HSA-5250986
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Clostridium botulinum
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
botG HC:LC binds SYT1 and GT1b on the target cell surface
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The botulinum toxin type G disulfide-bonded heavy chain - light chain heterodimer ("dichain") (botG HC:LC) binds ganglioside GT1b and synaptotagmin-1 (SYT1) on the plasma membrane of a human target cell. In vivo, this process specifically targets synapses at neuromuscular junctions, where toxin association with ganglioside may position it to bind efficiently to SYT1 when that protein is exposed at the cell surface by exocytosis (Peng et al. 2012; Willjes et al. 2013).
Literature References
PubMed ID Title Journal Year
23647335 Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity

Mahrhold, S, Strotmeier, J, Rummel, A, Eichner, T, Binz, T, Willjes, G

Biochemistry 2013
22454523 Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins

Pitkin, RM, Tepp, WH, Berntsson, RP, Stenmark, P, Dong, M, Peng, L, Johnson, EA

J. Cell. Sci. 2012
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
botulism DOID:11976 Botulism (disorder), Intoxication with Clostridium botulinum toxin, Botulism, Infection due to clostridium botulinum, Botulism, Foodborne botulism, botulism, Botulism, Botulism, Botulism, Food poisoning due to Clostridium botulinum, Botulism poisoning
Authored
Gopinathrao, G  (2006-06-15)
Krupa, S  (2006-06-15)
Reviewed
Ichtchenko, K  (2007-08-03)
Thirunavukkarasu, N  (2014-11-18)
Sharma, S  (2014-11-18)
Created
D'Eustachio, P  (2014-02-01)
Cite Us!