Reactome | Toxicity of botulinum toxin type B (botB)

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Toxicity of botulinum toxin type B (botB) Show undefined attributes

authored	[InstanceEdit:194836] Krupa, S, Gopinathrao, G, 2006-06-15 10:36:11
created	[InstanceEdit:5250954] D'Eustachio, Peter, 2014-01-31
crossReference	[DatabaseIdentifier:12020820] Mondo:0005498
dbId	5250958
disease	[Disease:3632909] botulism
displayName	Toxicity of botulinum toxin type B (botB)
edited	[InstanceEdit:5263589] D'Eustachio, Peter, 2014-02-10
eventOf	[Pathway:R-HSA-168799] Neurotoxicity of clostridium toxins - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-5228940] Transcytosis and dissociation of botB:NTNHA:HA - Homo sapiens [Reaction:R-HSA-5244397] botB HC:LC binds SYT1 or 2 and GT1b on the target cell surface - Homo sapiens [BlackBoxEvent:R-HSA-5244402] botB:SYT:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane - Homo sapiens [BlackBoxEvent:R-HSA-5244404] botB HC transports botB LC from target cell synaptic vesicle membrane into cytosol - Homo sapiens [Reaction:R-HSA-194796] botB LC cleaves target cell VAMP2 - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2020-12-07
literatureReference	[LiteratureReference:5228692] Crystal Structure of Clostridium botulinum Whole Hemagglutinin Reveals a Huge Triskelion-shaped Molecular Complex [LiteratureReference:194828] Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells [LiteratureReference:181771] Differences in the protease activities of tetanus and botulinum B toxins revealed by the cleavage of vesicle-associated membrane protein and various sized fragments [LiteratureReference:5228944] Uptake of botulinum neurotoxin in the intestine [LiteratureReference:5251396] Botulism: the present status of the disease [LiteratureReference:5228359] Botulinum neurotoxin: a marvel of protein design [LiteratureReference:5228352] Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin [LiteratureReference:379281] The synaptic vesicle cycle [LiteratureReference:5251719] Glycosphingolipids-sweets for botulinum neurotoxin
maxDepth	2
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	Toxicity of botulinum toxin type B (botB)
relatedSpecies	[Species:168825] Clostridium botulinum
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:201311] Ichtchenko, K, 2007-08-03 18:17:25 [InstanceEdit:5643756] Thirunavukkarasu, Nagarajan, Sharma, Shashi, 2014-11-17
revised	[InstanceEdit:5263589] D'Eustachio, Peter, 2014-02-10
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5250958
summation	[Summation:5251716] Botulinum toxin type B (botB, also known as BoNT/B), a disul...
updateTrackers	[UpdateTracker:9786034] Update Tracker - [Pathway:5250958] Toxicity of botulinum toxin type B (botB) - v50:[modifyText, updateContainedRLE] [UpdateTracker:9776493] Update Tracker - [Pathway:5250958] Toxicity of botulinum toxin type B (botB) - v75:[modifyText, updateContainedRLE]

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(updatedInstance)	[UpdateTracker:9786034] Update Tracker - [Pathway:5250958] Toxicity of botulinum toxin type B (botB) - v50:[modifyText, updateContainedRLE] [UpdateTracker:9776493] Update Tracker - [Pathway:5250958] Toxicity of botulinum toxin type B (botB) - v75:[modifyText, updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-168799] Neurotoxicity of clostridium toxins

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