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Schema
>
BlackBoxEvent
>
Entries
botB HC transports botB LC from target cell synaptic vesicle membrane into cytosol
Show undefined attributes
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authored
[InstanceEdit:194836] Krupa, S, Gopinathrao, G, 2006-06-15 10:36:11
catalystActivity
[CatalystActivity:5244423] protein transmembrane transporter activity of botB HC:LC:SYT:GT1b [synaptic vesicle membrane]
catalystActivityReference
[CatalystActivityReference:9643103] protein transmembrane transporter activity of BoNT/B:SYT:GT1b [synaptic vesicle membrane] Botulinum neurotoxin: a marvel of protein design
category
omitted
compartment
[Compartment:201753] synaptic vesicle membrane
[Compartment:70101] cytosol
created
[InstanceEdit:5244399] D'Eustachio, Peter, 2014-01-17
crossReference
[DatabaseIdentifier:12020820] Mondo:0005498
dbId
5244404
deleted
[Deleted:5250996] Deletion of instance: 181365
[Deleted:5251016] Deletion of instance: 168788
[Deleted:5250999] Deletion of instance: 181363
[Deleted:5251014] Deletion of instance: 181361
disease
[Disease:3632909] botulism
displayName
botB HC transports botB LC from target cell synaptic vesicle membrane into cytosol
eventOf
[Pathway:R-HSA-5250958] Toxicity of botulinum toxin type B (botB) - Homo sapiens
followingEvent
[Reaction:R-HSA-194796] botB LC cleaves target cell VAMP2 - Homo sapiens
input
[Complex:R-HSA-5244502] botB HC:LC:SYT:GT1b [synaptic vesicle membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:201296] Translocation of botulinum neurotoxin light chain protease through the heavy chain channel
[LiteratureReference:5228359] Botulinum neurotoxin: a marvel of protein design
[LiteratureReference:5244455] Receptor binding enables botulinum neurotoxin B to sense low pH for translocation channel assembly
[LiteratureReference:5244511] Botulinum neurotoxins B and E translocate at different rates and exhibit divergent responses to GT1b and low pH
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
botB HC transports botB LC from target cell synaptic vesicle membrane into cytosol
output
[EntityWithAccessionedSequence:R-CBO-5228953] botB HC [synaptic vesicle membrane]
[Complex:R-CBO-190016] botB LC:Zn2+ [cytosol]
[SimpleEntity:R-ALL-5244439] GT1b [synaptic vesicle membrane]
[DefinedSet:R-HSA-5324683] SYT1,2 [synaptic vesicle membrane]
precedingEvent
[BlackBoxEvent:R-HSA-5244402] botB:SYT:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane - Homo sapiens
regulatedBy
[PositiveRegulation:R-HSA-5244441] Positive regulation by 'H+ [synaptic vesicle lumen]'
regulationReference
[RegulationReference:9642575] Positive regulation by 'H+ [synaptic vesicle lumen]' Botulinum neurotoxin: a marvel of protein design
relatedSpecies
[Species:168825] Clostridium botulinum
releaseDate
2014-03-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:201311] Ichtchenko, K, 2007-08-03 18:17:25
[InstanceEdit:5643756] Thirunavukkarasu, Nagarajan, Sharma, Shashi, 2014-11-17
revised
[InstanceEdit:5263589] D'Eustachio, Peter, 2014-02-10
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-5244404
summation
[Summation:5262832] By analogy to the process described for botulinum toxin type...
updateTrackers
[UpdateTracker:9776477] Update Tracker - [BlackBoxEvent:5244404] botB HC transports botB LC from target cell synaptic vesicle membrane into cytosol - v75:[modifyText]
[UpdateTracker:9785987] Update Tracker - [BlackBoxEvent:5244404] botB HC transports botB LC from target cell synaptic vesicle membrane into cytosol - v50:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9776477] Update Tracker - [BlackBoxEvent:5244404] botB HC transports botB LC from target cell synaptic vesicle membrane into cytosol - v75:[modifyText]
[UpdateTracker:9785987] Update Tracker - [BlackBoxEvent:5244404] botB HC transports botB LC from target cell synaptic vesicle membrane into cytosol - v50:[modifyText]
(replacementInstances)
[Deleted:5250996] Deletion of instance: 181365
[Deleted:5251016] Deletion of instance: 168788
[Deleted:5250999] Deletion of instance: 181363
[Deleted:5251014] Deletion of instance: 181361
(precedingEvent)
[Reaction:R-HSA-194796] botB LC cleaves target cell VAMP2
(hasEvent)
[Pathway:R-HSA-5250958] Toxicity of botulinum toxin type B (botB)
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