Reactome | Transcytosis and dissociation of botA:NTNHA:HA

Schema > BlackBoxEvent > Entries

Transcytosis and dissociation of botA:NTNHA:HA Show undefined attributes

authored	[InstanceEdit:194836] Krupa, S, Gopinathrao, G, 2006-06-15 10:36:11
category	omitted
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:5228945] D'Eustachio, Peter, 2014-01-14
crossReference	[DatabaseIdentifier:12020820] Mondo:0005498
dbId	5228943
disease	[Disease:3632909] botulism
displayName	Transcytosis and dissociation of botA:NTNHA:HA
eventOf	[Pathway:R-HSA-5250968] Toxicity of botulinum toxin type A (botA) - Homo sapiens
followingEvent	[Reaction:R-HSA-5244415] botA HC:LC binds SV2A, B, or C and GT1b on the target cell surface - Homo sapiens
input	[Complex:R-CBO-5228604] botA HC:LC dimer:NTNHA:HA [extracellular region]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5228944] Uptake of botulinum neurotoxin in the intestine [LiteratureReference:5228606] Structure of a bimodular botulinum neurotoxin complex provides insights into its oral toxicity [LiteratureReference:5251392] Identification of the major steps in botulinum toxin action
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Transcytosis and dissociation of botA:NTNHA:HA
output	[Complex:R-CBO-5228590] botA HC:LC dimer [extracellular region] 3 × [EntityWithAccessionedSequence:R-CBO-5228602] ha17 [extracellular region] 6 × [EntityWithAccessionedSequence:R-CBO-5228607] ha33 [extracellular region] 3 × [EntityWithAccessionedSequence:R-CBO-5228591] ha70 [extracellular region] [EntityWithAccessionedSequence:R-CBO-5228601] NTNHA [extracellular region]
relatedSpecies	[Species:168825] Clostridium botulinum
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:201311] Ichtchenko, K, 2007-08-03 18:17:25 [InstanceEdit:5643756] Thirunavukkarasu, Nagarajan, Sharma, Shashi, 2014-11-17
revised	[InstanceEdit:5263589] D'Eustachio, Peter, 2014-02-10
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5228943
summation	[Summation:5251718] The bacterial botA:NTNHA:HA (BoNT/A:NTNHA:HA) complex, consi...
updateTrackers	[UpdateTracker:9786111] Update Tracker - [BlackBoxEvent:5228943] Transcytosis and dissociation of botA:NTNHA:HA - v50:[modifyText] [UpdateTracker:9776511] Update Tracker - [BlackBoxEvent:5228943] Transcytosis and dissociation of botA:NTNHA:HA - v75:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9786111] Update Tracker - [BlackBoxEvent:5228943] Transcytosis and dissociation of botA:NTNHA:HA - v50:[modifyText] [UpdateTracker:9776511] Update Tracker - [BlackBoxEvent:5228943] Transcytosis and dissociation of botA:NTNHA:HA - v75:[modifyText]
(precedingEvent)	[Reaction:R-HSA-5244415] botA HC:LC binds SV2A, B, or C and GT1b on the target cell surface
(hasEvent)	[Pathway:R-HSA-5250968] Toxicity of botulinum toxin type A (botA)