Reactome | botA HC:LC dimer [extracellular region]

Schema > Complex > Entries

compartment	[Compartment:984] extracellular region
componentOf	[Complex:R-CBO-5228604] botA HC:LC dimer:NTNHA:HA [extracellular region] - Clostridium botulinum
consumedByEvent	[Reaction:R-HSA-5244415] botA HC:LC binds SV2A, B, or C and GT1b on the target cell surface - Homo sapiens
created	[InstanceEdit:5228609] D'Eustachio, Peter, 2014-01-14
crossReference	[DatabaseIdentifier:12020820] Mondo:0005498
dbId	5228590
deleted	[Deleted:5251021] Deletion of instance: 181486
disease	[Disease:3632909] botulism
displayName	botA HC:LC dimer [extracellular region]
hasComponent	[EntityWithAccessionedSequence:R-CBO-9616783] botA HC disulfide bonded [extracellular region] [Complex:R-CBO-190046] botA LC:Zn2+ [extracellular region]
inDisease	true
isChimeric	false
literatureReference	[LiteratureReference:5228575] Crystal structure of botulinum neurotoxin type A and implications for toxicity
maxDepth	3
modified	[InstanceEdit:9704403] D'Eustachio, Peter, 2020-10-08
name	botA HC:LC dimer BoNT/A HC:LC dimer
producedByEvent	[BlackBoxEvent:R-HSA-5228943] Transcytosis and dissociation of botA:NTNHA:HA - Homo sapiens
schemaClass	Complex
species	[Species:168825] Clostridium botulinum
stId	R-CBO-5228590
updateTrackers	[UpdateTracker:9901794] Update Tracker - [Complex:5228590] botA HC:LC dimer [extracellular region] - v75:[addName, updateContainedComponent] [UpdateTracker:9899565] Update Tracker - [Complex:5228590] botA HC:LC dimer [extracellular region] - v66:[add_removeHasComponent, updateContainedComponent]

(updatedInstance)	[UpdateTracker:9901794] Update Tracker - [Complex:5228590] botA HC:LC dimer [extracellular region] - v75:[addName, updateContainedComponent] [UpdateTracker:9899565] Update Tracker - [Complex:5228590] botA HC:LC dimer [extracellular region] - v66:[add_removeHasComponent, updateContainedComponent]
(replacementInstances)	[Deleted:5251021] Deletion of instance: 181486
(input)	[Reaction:R-HSA-5244415] botA HC:LC binds SV2A, B, or C and GT1b on the target cell surface
(output)	[BlackBoxEvent:R-HSA-5228943] Transcytosis and dissociation of botA:NTNHA:HA
(hasComponent)	[Complex:R-CBO-5228604] botA HC:LC dimer:NTNHA:HA [extracellular region]