Reactome | RANBP2 SUMOylates TOP2A with SUMO1

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RANBP2 SUMOylates TOP2A with SUMO1 Show undefined attributes

authored	[InstanceEdit:4616035] May, B, 2013-09-27
catalystActivity	[CatalystActivity:3000418] SUMO transferase activity of Nuclear Pore Complex (NPC) [nuclear envelope]
catalystActivityReference	[CatalystActivityReference:9644133] SUMO transferase activity of Nuclear Pore Complex (NPC) [nuclear envelope] Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection
category	transition
compartment	[Compartment:7660] nucleoplasm [Compartment:13231] nuclear envelope
created	[InstanceEdit:5228504] May, B, 2014-01-13
dbId	5228525
displayName	RANBP2 SUMOylates TOP2A with SUMO1
edited	[InstanceEdit:4616035] May, B, 2013-09-27
eventOf	[Pathway:R-HSA-4615885] SUMOylation of DNA replication proteins - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:4162] protein sumoylation
inferredFrom	[Reaction:R-MMU-5228515] RanBP2 Sumoylates Top2a with Sumo1 - Mus musculus
input	[Complex:R-HSA-2993783] SUMO1:C93-UBE2I [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-1362276] TOP2A [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:4641337] Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha [LiteratureReference:5626900] Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RANBP2 SUMOylates TOP2A with SUMO1
output	[EntityWithAccessionedSequence:R-HSA-4641367] monoSUMO1-K-TOP2A [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-912481] UBE2I [nucleoplasm]
precedingEvent	[Reaction:R-HSA-2993790] Transfer of SUMO2 from E1 to UBE2I (UBC9) - Homo sapiens [Reaction:R-HSA-2993769] Transfer of SUMO3 from E1 to UBE2I (UBC9) - Homo sapiens
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6803017] Zhang, Xiang-Dong, 2015-10-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5228525
summation	[Summation:4641348] RANBP2 of the nuclear pore complex SUMOylates TOP2A with SUM...
updateTrackers	[UpdateTracker:9775077] Update Tracker - [Reaction:5228525] RANBP2 SUMOylates TOP2A with SUMO1 - v80:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9775077] Update Tracker - [Reaction:5228525] RANBP2 SUMOylates TOP2A with SUMO1 - v80:[add_removeOutput]
(hasEvent)	[Pathway:R-HSA-4615885] SUMOylation of DNA replication proteins
(inferredTo)	[Reaction:R-MMU-5228515] RanBP2 Sumoylates Top2a with Sumo1

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