RANBP2 SUMOylates TOP2A with SUMO1

Stable Identifier
R-HSA-5228525
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm, nuclear envelope
ReviewStatus
5/5
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RANBP2 SUMOylates TOP2A with SUMO1
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RANBP2 of the nuclear pore complex SUMOylates TOP2A with SUMO1 (Dawlaty et al. 2008, Impens et al. 2014). SUMOylated TOP2A is localized to centromeres. As inferred from mouse homologs, SUMOylation of TOP2A by RANBP2 is required for resolution of sister centromeres (Dawlaty et al. 2008).

Literature References
PubMed ID Title Journal Year
18394993 Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha

van Deursen, JM, Shuai, K, Kao, E, Jeganathan, KB, Tahk, S, Malureanu, L, Dawlaty, MM, Sustmann, C, Grosschedl, R

Cell 2008
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli

Impens, F, Cossart, P, Radoshevich, L, Ribet, D

Proc. Natl. Acad. Sci. U.S.A. 2014
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
protein sumoylation (0016925)
Catalyst Activity

SUMO transferase activity of Nuclear Pore Complex (NPC) [nuclear envelope]

Physical Entity
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Inferred From
RanBP2 Sumoylates Top2a with Sumo1 (Mus musculus)
Authored
May, B  (2013-09-27)
Reviewed
Zhang, XD  (2015-10-04)
Created
May, B  (2014-01-14)
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