Reactome | PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3)

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PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) Show undefined attributes

authored	[InstanceEdit:3214866] Jupe, S, 2013-03-12
catalystActivity	[CatalystActivity:5216240] histone methyltransferase activity of CCND1:CDK4:PRMT5:pT5-WDR77:COPRS [nucleoplasm]
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5216237] Jupe, S, 2013-12-16
dbId	5216234
displayName	PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3)
edited	[InstanceEdit:3215411] Jupe, S, 2013-03-15
eventOf	[Pathway:R-HSA-3214858] RMTs methylate histone arginines - Homo sapiens
input	2 × [SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm] [CandidateSet:R-HSA-181899] Histone H2A [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3215351] Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes [LiteratureReference:5212680] The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A
orthologousEvent	[BlackBoxEvent:R-DDI-5216234] PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) - Dictyostelium discoideum [BlackBoxEvent:R-XTR-5216234] PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) - Xenopus tropicalis [BlackBoxEvent:R-DRE-5216234] PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) - Danio rerio [BlackBoxEvent:R-SSC-5216234] PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) - Sus scrofa [BlackBoxEvent:R-BTA-5216234] PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) - Bos taurus [BlackBoxEvent:R-CFA-5216234] PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) - Canis familiaris
output	2 × [SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm] [CandidateSet:R-HSA-5218310] Me2sR4-histone H2A [nucleoplasm]
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5423560] Guccione, Ernesto, 2014-05-09 [InstanceEdit:5612458] Fischle, Wolfgang, 2014-07-23
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5216234
summation	[Summation:5218321] PRMT5 can methylate histone H2A at arginine-4 (H2AR3) (Pal e...
updateTrackers	[UpdateTracker:9786230] Update Tracker - [BlackBoxEvent:5216234] PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) - v50:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9786230] Update Tracker - [BlackBoxEvent:5216234] PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) - v50:[modifyText]
(hasEvent)	[Pathway:R-HSA-3214858] RMTs methylate histone arginines

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