Reactome | SYK is a substrate for JAK1

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SYK is a substrate for JAK1 Show undefined attributes

authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
catalystActivity	[CatalystActivity:508440] protein tyrosine kinase activity of IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643374] protein tyrosine kinase activity of IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:508272] Jupe, S, 2010-02-11
dbId	508282
displayName	SYK is a substrate for JAK1
edited	[InstanceEdit:924611] Jupe, S, 2010-08-06
eventOf	[Pathway:R-HSA-9020558] Interleukin-2 signaling - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-508449] IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:451930] Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	SYK is a substrate for JAK1
orthologousEvent	[Reaction:R-SSC-508282] SYK is a substrate for JAK1 - Sus scrofa [Reaction:R-BTA-508282] SYK is a substrate for JAK1 - Bos taurus [Reaction:R-CFA-508282] SYK is a substrate for JAK1 - Canis familiaris [Reaction:R-RNO-508282] SYK is a substrate for JAK1 - Rattus norvegicus [Reaction:R-MMU-508282] SYK is a substrate for JAK1 - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-508438] IL2:IL2R trimer:p-JAK1:JAK3:p-SYK [plasma membrane]
precedingEvent	[Reaction:R-HSA-508292] SYK binds IL2RB - Homo sapiens
releaseDate	2011-03-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1213492] Villarino, A, 2011-02-11 [InstanceEdit:1233246] Dooms, H, 2011-03-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-508282
summation	[Summation:508299] Studies have shown that coexpression of Syk with catalytical...
updateTrackers	[UpdateTracker:9779110] Update Tracker - [Reaction:508282] SYK is a substrate for JAK1 - v66:[addInput, addOutput]

Referrals

(updatedInstance)	[UpdateTracker:9779110] Update Tracker - [Reaction:508282] SYK is a substrate for JAK1 - v66:[addInput, addOutput]
(hasEvent)	[Pathway:R-HSA-9020558] Interleukin-2 signaling