Studies have shown that coexpression of Syk with catalytically active Jak1 results in Syk phosphorylation whereas coexpression of Syk with catalytically active Jak3 does not, suggesting that IL-2 driven phosphorylation of Syk is driven by Jak1 (Zhou et al. 2000).
Changelian, PS, Cheng, TP, Frucht, DM, Candotti, F, Zhou, YJ, Geahlen, RL, Galon, J, Magnuson, KS, Gadina, M, O'Shea, JJ
protein tyrosine kinase activity of IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane]
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