SYK is a substrate for JAK1

Stable Identifier
R-HSA-508282
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane
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SYK is a substrate for JAK1
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Studies have shown that coexpression of Syk with catalytically active Jak1 results in Syk phosphorylation whereas coexpression of Syk with catalytically active Jak3 does not, suggesting that IL-2 driven phosphorylation of Syk is driven by Jak1 (Zhou et al. 2000).

Literature References
PubMed ID Title Journal Year
10825200 Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation

Changelian, PS, Cheng, TP, Frucht, DM, Candotti, F, Zhou, YJ, Geahlen, RL, Galon, J, Magnuson, KS, Gadina, M, O'Shea, JJ

Mol Cell Biol 2000
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane]

Physical Entity
IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
SYK is a substrate for JAK1 (Mus musculus)
SYK is a substrate for JAK1 (Rattus norvegicus)
Authored
Ray, KP  (2010-05-17)
Reviewed
Dooms, H  (2011-03-17)
Villarino, A  (2011-02-11)
Created
Jupe, S  (2010-02-11)
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