Reactome | GPCR ligand binding

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GPCR ligand binding Show undefined attributes

authored	[InstanceEdit:500793] Jassal, B, 2010-02-05
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:500791] Jassal, B, 2010-02-05
dbId	500792
displayName	GPCR ligand binding
edited	[InstanceEdit:507975] Jupe, S, 2010-02-10
eventOf	[Pathway:R-HSA-372790] Signaling by GPCR - Homo sapiens
figure	[Figure:9628912] /figures/ehld/R-HSA-500792.svg
hasDiagram	true
hasEHLD	true
hasEvent	[Pathway:R-HSA-373076] Class A/1 (Rhodopsin-like receptors) - Homo sapiens [Pathway:R-HSA-373080] Class B/2 (Secretin family receptors) - Homo sapiens [Pathway:R-HSA-420499] Class C/3 (Metabotropic glutamate/pheromone receptors) - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-06-09
literatureReference	[LiteratureReference:508596] Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis approaches to receptor structure and function
maxDepth	5
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	GPCR ligand binding
orthologousEvent	[Pathway:R-MMU-500792] GPCR ligand binding - Mus musculus [Pathway:R-RNO-500792] GPCR ligand binding - Rattus norvegicus [Pathway:R-CFA-500792] GPCR ligand binding - Canis familiaris [Pathway:R-BTA-500792] GPCR ligand binding - Bos taurus [Pathway:R-SSC-500792] GPCR ligand binding - Sus scrofa [Pathway:R-DRE-500792] GPCR ligand binding - Danio rerio [Pathway:R-XTR-500792] GPCR ligand binding - Xenopus tropicalis [Pathway:R-GGA-500792] GPCR ligand binding - Gallus gallus [Pathway:R-DME-500792] GPCR ligand binding - Drosophila melanogaster [Pathway:R-CEL-500792] GPCR ligand binding - Caenorhabditis elegans [Pathway:R-DDI-500792] GPCR ligand binding - Dictyostelium discoideum [Pathway:R-SPO-500792] GPCR ligand binding - Schizosaccharomyces pombe [Pathway:R-SCE-500792] GPCR ligand binding - Saccharomyces cerevisiae
releaseDate	2010-03-16
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:450112] D'Eustachio, P, 2009-12-11
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-500792
summation	[Summation:508595] There are more than 800 G-protein coupled receptor (GPCRs) i...
updateTrackers	[UpdateTracker:9790134] Update Tracker - [Pathway:500792] GPCR ligand binding - v35:[updateContainedPathway] [UpdateTracker:9782332] Update Tracker - [Pathway:500792] GPCR ligand binding - v59:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9775886] Update Tracker - [Pathway:500792] GPCR ligand binding - v78:[updateContainedPathway] [UpdateTracker:9774634] Update Tracker - [Pathway:500792] GPCR ligand binding - v81:[updateContainedPathway] [UpdateTracker:9783400] Update Tracker - [Pathway:500792] GPCR ligand binding - v56:[updateContainedPathway] [UpdateTracker:9776210] Update Tracker - [Pathway:500792] GPCR ligand binding - v77:[updateContainedPathway] [UpdateTracker:9788442] Update Tracker - [Pathway:500792] GPCR ligand binding - v42:[updateContainedPathway] [UpdateTracker:9790333] Update Tracker - [Pathway:500792] GPCR ligand binding - v34:[updateContainedPathway] [UpdateTracker:9780475] Update Tracker - [Pathway:500792] GPCR ligand binding - v63:[updateIndirectRLE] [UpdateTracker:9788539] Update Tracker - [Pathway:500792] GPCR ligand binding - v41:[updateContainedPathway] [UpdateTracker:9789163] Update Tracker - [Pathway:500792] GPCR ligand binding - v38:[modifyText] [UpdateTracker:9789585] Update Tracker - [Pathway:500792] GPCR ligand binding - v37:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9784542] Update Tracker - [Pathway:500792] GPCR ligand binding - v54:[updateContainedPathway] [UpdateTracker:9786500] Update Tracker - [Pathway:500792] GPCR ligand binding - v49:[updateContainedPathway] [UpdateTracker:9780133] Update Tracker - [Pathway:500792] GPCR ligand binding - v64:[modifyText] [UpdateTracker:9776687] Update Tracker - [Pathway:500792] GPCR ligand binding - v74:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9778946] Update Tracker - [Pathway:500792] GPCR ligand binding - v67:[updateContainedPathway] [UpdateTracker:9776570] Update Tracker - [Pathway:500792] GPCR ligand binding - v75:[updateIndirectRLE] [UpdateTracker:9787476] Update Tracker - [Pathway:500792] GPCR ligand binding - v45:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9790407] Update Tracker - [Pathway:500792] GPCR ligand binding - v33:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9781685] Update Tracker - [Pathway:500792] GPCR ligand binding - v60:[updateContainedPathway] [UpdateTracker:9788196] Update Tracker - [Pathway:500792] GPCR ligand binding - v43:[updateContainedPathway] [UpdateTracker:9779009] Update Tracker - [Pathway:500792] GPCR ligand binding - v66:[updateContainedPathway]

Referrals

(hasEvent)

[Pathway:R-HSA-372790] Signaling by GPCR

(updatedInstance)

[UpdateTracker:9790134] Update Tracker - [Pathway:500792] GPCR ligand binding - v35:[updateContainedPathway]
[UpdateTracker:9782332] Update Tracker - [Pathway:500792] GPCR ligand binding - v59:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9775886] Update Tracker - [Pathway:500792] GPCR ligand binding - v78:[updateContainedPathway]
[UpdateTracker:9774634] Update Tracker - [Pathway:500792] GPCR ligand binding - v81:[updateContainedPathway]
[UpdateTracker:9783400] Update Tracker - [Pathway:500792] GPCR ligand binding - v56:[updateContainedPathway]
[UpdateTracker:9776210] Update Tracker - [Pathway:500792] GPCR ligand binding - v77:[updateContainedPathway]
[UpdateTracker:9788442] Update Tracker - [Pathway:500792] GPCR ligand binding - v42:[updateContainedPathway]
[UpdateTracker:9790333] Update Tracker - [Pathway:500792] GPCR ligand binding - v34:[updateContainedPathway]
[UpdateTracker:9780475] Update Tracker - [Pathway:500792] GPCR ligand binding - v63:[updateIndirectRLE]
[UpdateTracker:9788539] Update Tracker - [Pathway:500792] GPCR ligand binding - v41:[updateContainedPathway]
[UpdateTracker:9789163] Update Tracker - [Pathway:500792] GPCR ligand binding - v38:[modifyText]
[UpdateTracker:9789585] Update Tracker - [Pathway:500792] GPCR ligand binding - v37:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9784542] Update Tracker - [Pathway:500792] GPCR ligand binding - v54:[updateContainedPathway]
[UpdateTracker:9786500] Update Tracker - [Pathway:500792] GPCR ligand binding - v49:[updateContainedPathway]
[UpdateTracker:9780133] Update Tracker - [Pathway:500792] GPCR ligand binding - v64:[modifyText]
[UpdateTracker:9776687] Update Tracker - [Pathway:500792] GPCR ligand binding - v74:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9778946] Update Tracker - [Pathway:500792] GPCR ligand binding - v67:[updateContainedPathway]
[UpdateTracker:9776570] Update Tracker - [Pathway:500792] GPCR ligand binding - v75:[updateIndirectRLE]
[UpdateTracker:9787476] Update Tracker - [Pathway:500792] GPCR ligand binding - v45:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9790407] Update Tracker - [Pathway:500792] GPCR ligand binding - v33:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9781685] Update Tracker - [Pathway:500792] GPCR ligand binding - v60:[updateContainedPathway]
[UpdateTracker:9788196] Update Tracker - [Pathway:500792] GPCR ligand binding - v43:[updateContainedPathway]
[UpdateTracker:9779009] Update Tracker - [Pathway:500792] GPCR ligand binding - v66:[updateContainedPathway]

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