Reactome | CTNNB1 S37 mutants aren't phosphorylated by GSK3beta

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CTNNB1 S37 mutants aren't phosphorylated by GSK3beta Show undefined attributes

authored	[InstanceEdit:4837328] Rothfels, K, 2013-10-30
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:4839636] Rothfels, K, 2013-11-01
dbId	4839635
disease	[Disease:1500689] cancer
displayName	CTNNB1 S37 mutants aren't phosphorylated by GSK3beta
edited	[InstanceEdit:5358774] Matthews, Lisa, 2014-04-03
entityFunctionalStatus	[EntityFunctionalStatus:4839620] loss_of_function of pT41,S45-CTNNB1 S37 mutants:Axin:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol]
eventOf	[Pathway:R-HSA-5358749] CTNNB1 S37 mutants aren't phosphorylated - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-4839622] pT41,S45-CTNNB1 S37 mutants:Axin:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5255458] beta-Catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer [LiteratureReference:5251531] Nuclear accumulation of mutated beta-catenin in hepatocellular carcinoma is associated with increased cell proliferation [LiteratureReference:5246618] Wnt signaling and cancer
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CTNNB1 S37 mutants aren't phosphorylated by GSK3beta
normalReaction	[Reaction:R-HSA-195283] Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5433076] Salahshor, S, 2014-05-12 [InstanceEdit:5545509] Woodgett, Jim, 2014-05-21
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4839635
summation	[Summation:5255473] S37 mutations of beta-catenin interfere with GSK3 phosphoryl...

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[Pathway:R-HSA-5358749] CTNNB1 S37 mutants aren't phosphorylated

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