Reactome | pT41,S45-CTNNB1 S37F [cytosol]

Schema > EntityWithAccessionedSequence > Entries

pT41,S45-CTNNB1 S37F [cytosol] Show undefined attributes

candidateOf	[CandidateSet:R-HSA-4839616] pT41,S45-CTNNB1 S37 mutants [cytosol] - Homo sapiens
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:4839618] Rothfels, K, 2013-11-01
crossReference	[DatabaseIdentifier:12021310] Mondo:0002529 [DatabaseIdentifier:4839569] COSMIC:COSV62687856
dbId	4839621
disease	[Disease:1500689] cancer [Disease:2317358] endometrial cancer [Disease:2327993] hepatocellular carcinoma [Disease:2328001] skin squamous cell carcinoma [Disease:2328198] pancreatic cancer [Disease:1500687] stomach cancer
displayName	pT41,S45-CTNNB1 S37F [cytosol]
endCoordinate	781
hasModifiedResidue	[ModifiedResidue:4839603] O-phospho-L-serine at 45 [ModifiedResidue:4839605] O-phospho-L-threonine at 41 [ReplacedResidue:4839598] L-serine 37 replaced with L-phenylalanine
inDisease	true
literatureReference	[LiteratureReference:5255458] beta-Catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer [LiteratureReference:5251472] Abnormalities of the APC/beta-catenin pathway in endometrial cancer [LiteratureReference:5255505] Beta-catenin mutations are specific for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway
maxDepth	1
modified	[InstanceEdit:8865006] Rothfels, Karen, 2016-03-17
name	pT41,S45-CTNNB1 S37F p-T41,S45-beta catenin S37C
referenceEntity	[ReferenceGeneProduct:uniprot:P35222] UniProt:P35222 CTNNB1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-4839621
startCoordinate	1

Referrals

(hasCandidate)

[CandidateSet:R-HSA-4839616] pT41,S45-CTNNB1 S37 mutants [cytosol]

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