Reactome | pT41,S45-CTNNB1 S37A [cytosol]

Schema > EntityWithAccessionedSequence > Entries

candidateOf	[CandidateSet:R-HSA-4839616] pT41,S45-CTNNB1 S37 mutants [cytosol] - Homo sapiens
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:4839618] Rothfels, K, 2013-11-01
crossReference	[DatabaseIdentifier:12020782] Mondo:0001056 [DatabaseIdentifier:4839575] COSMIC:COSV62688488
dbId	4839619
disease	[Disease:1500689] cancer [Disease:1500687] stomach cancer [Disease:4791250] colorectal cancer
displayName	pT41,S45-CTNNB1 S37A [cytosol]
endCoordinate	781
hasModifiedResidue	[ModifiedResidue:4839603] O-phospho-L-serine at 45 [ModifiedResidue:4839605] O-phospho-L-threonine at 41 [ReplacedResidue:4839594] L-serine 37 replaced with L-alanine
inDisease	true
literatureReference	[LiteratureReference:5251485] Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis [LiteratureReference:5255458] beta-Catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer [LiteratureReference:5251469] AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1
maxDepth	1
modified	[InstanceEdit:5255510] Rothfels, K, 2014-02-06
name	pT41,S45-CTNNB1 S37A p-T41,S45-beta catenin S37A
referenceEntity	[ReferenceGeneProduct:uniprot:P35222] UniProt:P35222 CTNNB1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-4839619
startCoordinate	1

(hasCandidate)

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