Reactome | Defective MOGS does not cleave glucose from an N-glycosylated protein

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Defective MOGS does not cleave glucose from an N-glycosylated protein Show undefined attributes

authored	[InstanceEdit:4043910] Jassal, B, 2013-07-29
catalystActivity	[CatalystActivity:9631931] Glc3Man9GlcNAc2 oligosaccharide glucosidase activity of MOGS mutants [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:4793951] Jassal, B, 2013-10-29
crossReference	[DatabaseIdentifier:12020881] Mondo:0005501
dbId	4793947
disease	[Disease:3656242] congenital disorder of glycosylation type II
displayName	Defective MOGS does not cleave glucose from an N-glycosylated protein
edited	[InstanceEdit:4793951] Jassal, B, 2013-10-29
entityFunctionalStatus	[EntityFunctionalStatus:4839803] loss_of_function of MOGS mutants [endoplasmic reticulum membrane]
eventOf	[Pathway:R-HSA-4793954] Defective MOGS causes CDG-2b - Homo sapiens
input	[Complex:R-HSA-532534] unfolded protein:(Glc)3 (GlcNAc)2 (Man)9 (Asn)1 [endoplasmic reticulum lumen]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:532704] A novel disorder caused by defective biosynthesis of N-linked oligosaccharides due to glucosidase I deficiency [LiteratureReference:532701] Processing of N-linked carbohydrate chains in a patient with glucosidase I deficiency (CDG type IIb)
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Defective MOGS does not cleave glucose from an N-glycosylated protein
normalReaction	[Reaction:R-HSA-532678] Trimming of the first glucose by by mannosyl-oligosaccharide glucosidase
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5633220] Belaya, Katsiaryna, 2014-10-31
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4793947
summation	[Summation:4839840] After the lipid-linked oligosaccharide (LLO) precursor is at...
systematicName	MOGS mutants do not cleave Glc from unfolded protein:(Glc)3 (GlcNAc)2 (Man)9 (Asn)1
updateTrackers	[UpdateTracker:9778366] Update Tracker - [FailedReaction:4793947] Defective MOGS does not cleave glucose from an N-glycosylated protein - v68:[addCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9778366] Update Tracker - [FailedReaction:4793947] Defective MOGS does not cleave glucose from an N-glycosylated protein - v68:[addCatalystActivity]
(hasEvent)	[Pathway:R-HSA-4793954] Defective MOGS causes CDG-2b

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