Reactome | HSF1:HSP90:PTGES3 [cytosol]

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HSF1:HSP90:PTGES3 [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
consumedByEvent	[Reaction:R-HSA-3371586] Dissociation of cytosolic HSF1:HSP90 complex - Homo sapiens
created	[InstanceEdit:4793918] Shamovsky, V, 2013-10-28
dbId	4793919
displayName	HSF1:HSP90:PTGES3 [cytosol]
hasComponent	[EntityWithAccessionedSequence:R-HSA-3371452] HSF1 [cytosol] [DefinedSet:R-HSA-3371429] HSP90:HSP90 [cytosol] 2 × [EntityWithAccessionedSequence:R-HSA-265269] PTGES3 [cytosol]
inDisease	false
inferredTo	[Complex:R-MMU-4793919] HSF1:HSP90:PTGES3 [cytosol] - Mus musculus [Complex:R-RNO-4793919] HSF1:HSP90:PTGES3 [cytosol] - Rattus norvegicus [Complex:R-BTA-4793919] HSF1:HSP90:PTGES3 [cytosol] - Bos taurus [Complex:R-SSC-4793919] HSF1:HSP90:PTGES3 [cytosol] - Sus scrofa [Complex:R-DRE-4793919] HSF1:HSP90:PTGES3 [cytosol] - Danio rerio [Complex:R-GGA-4793919] HSF1:HSP90:PTGES3 [cytosol] - Gallus gallus [Complex:R-DME-4793919] HSF1:HSP90:PTGES3 [cytosol] - Drosophila melanogaster [Complex:R-CEL-4793919] HSF1:HSP90:PTGES3 [cytosol] - Caenorhabditis elegans [Complex:R-DDI-4793919] HSF1:HSP90:PTGES3 [cytosol] - Dictyostelium discoideum [Complex:R-SPO-4793919] HSF1:HSP90:PTGES3 [cytosol] - Schizosaccharomyces pombe [Complex:R-SCE-4793919] HSF1:HSP90:PTGES3 [cytosol] - Saccharomyces cerevisiae
isChimeric	false
literatureReference	[LiteratureReference:4793649] Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1 [LiteratureReference:4793647] Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex [LiteratureReference:5324669] The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins [LiteratureReference:5324657] N-terminal domain of human Hsp90 triggers binding to the cochaperone p23
maxDepth	4
modified	[InstanceEdit:5324681] Shamovsky, V, 2014-02-17
name	HSF1:HSP90:PTGES3
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-4793919
updateTrackers	[UpdateTracker:9902004] Update Tracker - [Complex:4793919] HSF1:HSP90:PTGES3 [cytosol] - v76:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9902004] Update Tracker - [Complex:4793919] HSF1:HSP90:PTGES3 [cytosol] - v76:[updateContainedComponent]
(input)	[Reaction:R-HSA-3371586] Dissociation of cytosolic HSF1:HSP90 complex

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