Reactome | CTNNB1 S45P [cytosol]

Schema > EntityWithAccessionedSequence > Entries

candidateOf	[CandidateSet:R-HSA-4791274] CTNNB1 S45 mutants [cytosol] - Homo sapiens
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:4791271] Rothfels, K, 2013-10-28
crossReference	[DatabaseIdentifier:12020837] Mondo:0002367 [DatabaseIdentifier:4791258] COSMIC:COSM12639 [DatabaseIdentifier:5251421] COSMIC:COSV62687880
dbId	4791272
disease	[Disease:1500689] cancer [Disease:2327993] hepatocellular carcinoma [Disease:1655484] kidney cancer [Disease:4791250] colorectal cancer [Disease:4791269] adrenal gland cancer [Disease:4839609] connective tissue cancer
displayName	CTNNB1 S45P [cytosol]
endCoordinate	781
hasModifiedResidue	[ReplacedResidue:4791266] L-serine 45 replaced with L-proline
inDisease	true
literatureReference	[LiteratureReference:5251469] AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1 [LiteratureReference:5251510] Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas [LiteratureReference:5251529] Nuclear accumulation of beta-catenin protein in Wilms' tumours
maxDepth	1
modified	[InstanceEdit:5251585] Rothfels, K, 2014-02-04
name	CTNNB1 S45P Catenin beta-1 CTNB1_HUMAN
referenceEntity	[ReferenceGeneProduct:uniprot:P35222] UniProt:P35222 CTNNB1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-4791272
startCoordinate	1

(hasCandidate)

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