Reactome | PIAS1 SUMOylates SATB1 with SUMO2,3

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PIAS1 SUMOylates SATB1 with SUMO2,3 Show undefined attributes

authored	[InstanceEdit:4570563] May, B, 2013-09-21
catalystActivity	[CatalystActivity:3247478] SUMO transferase activity of PIAS1 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643901] SUMO transferase activity of PIAS1 [nucleoplasm] Transcription factor Sp3 is silenced through SUMO modification by PIAS1
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4615844] May, B, 2013-09-27
dbId	4615839
displayName	PIAS1 SUMOylates SATB1 with SUMO2,3
edited	[InstanceEdit:4570563] May, B, 2013-09-21
eventOf	[Pathway:R-HSA-4551638] SUMOylation of chromatin organization proteins - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-201593] SATB1 [nucleoplasm] 2 × [DefinedSet:R-HSA-3899312] UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4616023] SUMO conjugation to the matrix attachment region-binding protein, special AT-rich sequence-binding protein-1 (SATB1), targets SATB1 to promyelocytic nuclear bodies where it undergoes caspase cleavage [LiteratureReference:4615896] Phosphorylation-dependent interaction of SATB1 and PIAS1 directs SUMO-regulated caspase cleavage of SATB1 [LiteratureReference:5627513] Proteome-wide identification of SUMO2 modification sites
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	PIAS1 SUMOylates SATB1 with SUMO2,3
orthologousEvent	[Reaction:R-DME-4615839] PIAS1 SUMOylates SATB1 with SUMO2,3 - Drosophila melanogaster [Reaction:R-GGA-4615839] PIAS1 SUMOylates SATB1 with SUMO2,3 - Gallus gallus [Reaction:R-XTR-4615839] PIAS1 SUMOylates SATB1 with SUMO2,3 - Xenopus tropicalis [Reaction:R-DRE-4615839] PIAS1 SUMOylates SATB1 with SUMO2,3 - Danio rerio [Reaction:R-SSC-4615839] PIAS1 SUMOylates SATB1 with SUMO2,3 - Sus scrofa [Reaction:R-BTA-4615839] PIAS1 SUMOylates SATB1 with SUMO2,3 - Bos taurus [Reaction:R-RNO-4615839] PIAS1 SUMOylates SATB1 with SUMO2,3 - Rattus norvegicus [Reaction:R-MMU-4615839] PIAS1 SUMOylates SATB1 with SUMO2,3 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-4615978] polySUMO2,3-K744-SATB1 [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-HSA-912481] UBE2I [nucleoplasm]
precedingEvent	[Reaction:R-HSA-2993790] Transfer of SUMO2 from E1 to UBE2I (UBC9) - Homo sapiens [Reaction:R-HSA-2993769] Transfer of SUMO3 from E1 to UBE2I (UBC9) - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8956382] Lu, Jian, 2017-01-22 [InstanceEdit:8956359] Matunis, Michael J, 2017-01-22 [InstanceEdit:8956371] Yang, Wei-Chih, 2017-01-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4615839
summation	[Summation:4615898] PIAS1 SUMOylates SATB1 at lysine-744 with SUMO2,3 (Tan et al...

Referrals

(hasEvent)

[Pathway:R-HSA-4551638] SUMOylation of chromatin organization proteins