Reactome | PIAS1 SUMOylates SATB1 with SUMO2,3

PIAS1 SUMOylates SATB1 with SUMO2,3

Stable Identifier

R-HSA-4615839

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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PIAS1 SUMOylates SATB1 at lysine-744 with SUMO2,3 (Tan et al. 2008, Tan et al. 2010, Tammsalu et al. 2014). SUMOylation targets SATB1 to PML bodies where it is cleaved by caspase.

Literature References

PubMed ID	Title	Journal	Year
20351170	Phosphorylation-dependent interaction of SATB1 and PIAS1 directs SUMO-regulated caspase cleavage of SATB1 Tan, JA, Song, J, Chen, Y, Durrin, LK	Mol. Cell. Biol.	2010
24782567	Proteome-wide identification of SUMO2 modification sites Tammsalu, T, Matic, I, Jaffray, EG, Ibrahim, AF, Tatham, MH, Hay, RT	Sci Signal	2014
18408014	SUMO conjugation to the matrix attachment region-binding protein, special AT-rich sequence-binding protein-1 (SATB1), targets SATB1 to promyelocytic nuclear bodies where it undergoes caspase cleavage Tan, JA, Sun, Y, Song, J, Chen, Y, Krontiris, TG, Durrin, LK	J. Biol. Chem.	2008