Reactome | ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs

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ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs Show undefined attributes

authored	[InstanceEdit:451187] May, B, 2009-12-29
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:450588] May, B, 2009-12-16
dbId	450400
displayName	ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs
edited	[InstanceEdit:451187] May, B, 2009-12-29
eventOf	[Pathway:R-HSA-450513] Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA - Homo sapiens
followingEvent	[Reaction:R-HSA-450463] MK2 phosphorylates ZFP36 (Tristetraproline, TTP) - Homo sapiens [Reaction:R-HSA-450431] ZFP36 (TTP) recruits RNA degradation activities - Homo sapiens
input	[OtherEntity:R-ALL-450597] mRNA Transcript Targeted by Tristetraproline [cytosol] [EntityWithAccessionedSequence:R-HSA-180743] TNPO1 [cytosol] [EntityWithAccessionedSequence:R-HSA-450562] ZFP36 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:451191] TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements [LiteratureReference:451176] A role for transportin in deposition of TTP to cytoplasmic RNA granules and mRNA decay [LiteratureReference:451112] Identification of TTP mRNA targets in human dendritic cells reveals TTP as a critical regulator of dendritic cell maturation [LiteratureReference:451167] Tristetraprolin recruits functional mRNA decay complexes to ARE sequences [LiteratureReference:451217] RNA sequence elements required for high affinity binding by the zinc finger domain of tristetraprolin: conformational changes coupled to the bipartite nature of Au-rich MRNA-destabilizing motifs [LiteratureReference:451107] Selective RNA binding by a single CCCH zinc-binding domain from Nup475 (Tristetraprolin) [LiteratureReference:451199] Expression and purification of recombinant tristetraprolin that can bind to tumor necrosis factor-alpha mRNA and serve as a substrate for mitogen-activated protein kinases [LiteratureReference:451172] Characteristics of the interaction of a synthetic human tristetraprolin tandem zinc finger peptide with AU-rich element-containing RNA substrates [LiteratureReference:451150] RNA binding properties of the AU-rich element-binding recombinant Nup475/TIS11/tristetraprolin protein [LiteratureReference:451095] Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs
orthologousEvent	[Reaction:R-SCE-450400] ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs - Saccharomyces cerevisiae [Reaction:R-DDI-450400] ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs - Dictyostelium discoideum [Reaction:R-CEL-450400] ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs - Caenorhabditis elegans [Reaction:R-DME-450400] ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs - Drosophila melanogaster [Reaction:R-XTR-450400] ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs - Xenopus tropicalis [Reaction:R-DRE-450400] ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs - Danio rerio [Reaction:R-SSC-450400] ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs - Sus scrofa [Reaction:R-BTA-450400] ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs - Bos taurus [Reaction:R-RNO-450400] ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs - Rattus norvegicus [Reaction:R-MMU-450400] ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs - Mus musculus
output	[Complex:R-HSA-450365] TTP:mRNA Complex [cytosol]
precedingEvent	[Reaction:R-HSA-75098] mRNP complex dissociates from cytosolic face of NPC - Homo sapiens
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:882027] Wilusz, J, 2010-06-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-450400
summation	[Summation:451124] Tristetraprolin (TTP) binds UUAUUUAUU motifs in the AU-rich ...

Referrals

(precedingEvent)	[Reaction:R-HSA-450463] MK2 phosphorylates ZFP36 (Tristetraproline, TTP) [Reaction:R-HSA-450431] ZFP36 (TTP) recruits RNA degradation activities
(hasEvent)	[Pathway:R-HSA-450513] Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA

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