Reactome | IRAK4-activated IRAK1 autophosphorylates

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IRAK4-activated IRAK1 autophosphorylates Show undefined attributes

authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
catalystActivity	[CatalystActivity:446883] protein serine/threonine kinase activity of IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:446679] Jupe, S, 2009-11-16
dbId	446701
displayName	IRAK4-activated IRAK1 autophosphorylates
edited	[InstanceEdit:744683] Jupe, S, 2010-05-17
eventOf	[Pathway:R-HSA-9020702] Interleukin-1 signaling - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-446689] IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:165896] Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	IRAK4-activated IRAK1 autophosphorylates
orthologousEvent	[Reaction:R-BTA-446701] IRAK4-activated IRAK1 autophosphorylates - Bos taurus [Reaction:R-SSC-446701] IRAK4-activated IRAK1 autophosphorylates - Sus scrofa [Reaction:R-CFA-446701] IRAK4-activated IRAK1 autophosphorylates - Canis familiaris [Reaction:R-RNO-446701] IRAK4-activated IRAK1 autophosphorylates - Rattus norvegicus [Reaction:R-MMU-446701] IRAK4-activated IRAK1 autophosphorylates - Mus musculus
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-446696] IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane]
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:744680] Pinteaux, E, 2010-05-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-446701
summation	[Summation:446704] A series of sequential phosphorylation events lead to full o...

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[Pathway:R-HSA-9020702] Interleukin-1 signaling

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