Reactome | Interleukin-1 family signaling

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Interleukin-1 family signaling Show undefined attributes

authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:446650] Jupe, S, 2009-11-16
dbId	446652
displayName	Interleukin-1 family signaling
edited	[InstanceEdit:744683] Jupe, S, 2010-05-17
eventOf	[Pathway:R-HSA-449147] Signaling by Interleukins - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:8651] cytokine-mediated signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-448706] Interleukin-1 processing - Homo sapiens [Pathway:R-HSA-9020702] Interleukin-1 signaling - Homo sapiens [Pathway:R-HSA-9012546] Interleukin-18 signaling - Homo sapiens [Pathway:R-HSA-9014843] Interleukin-33 signaling - Homo sapiens [Pathway:R-HSA-9014826] Interleukin-36 pathway - Homo sapiens [Pathway:R-HSA-9008059] Interleukin-37 signaling - Homo sapiens [Pathway:R-HSA-9007892] Interleukin-38 signaling - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-06-09
literatureReference	[LiteratureReference:9020903] The interleukin (IL)-1 cytokine family--Balance between agonists and antagonists in inflammatory diseases [LiteratureReference:451657] Immunological and inflammatory functions of the interleukin-1 family [LiteratureReference:451412] The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling [LiteratureReference:5607865] IL-1, IL-18, and IL-33 families of cytokines
maxDepth	5
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Interleukin-1 family signaling
orthologousEvent	[Pathway:R-RNO-446652] Interleukin-1 family signaling - Rattus norvegicus [Pathway:R-CFA-446652] Interleukin-1 family signaling - Canis familiaris [Pathway:R-SSC-446652] Interleukin-1 family signaling - Sus scrofa [Pathway:R-DRE-446652] Interleukin-1 family signaling - Danio rerio [Pathway:R-DDI-446652] Interleukin-1 family signaling - Dictyostelium discoideum [Pathway:R-DME-446652] Interleukin-1 family signaling - Drosophila melanogaster [Pathway:R-CEL-446652] Interleukin-1 family signaling - Caenorhabditis elegans [Pathway:R-GGA-446652] Interleukin-1 family signaling - Gallus gallus [Pathway:R-MMU-446652] Interleukin-1 family signaling - Mus musculus [Pathway:R-XTR-446652] Interleukin-1 family signaling - Xenopus tropicalis [Pathway:R-BTA-446652] Interleukin-1 family signaling - Bos taurus
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:744680] Pinteaux, E, 2010-05-17
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-446652
summation	[Summation:9020901] The Interleukin-1 (IL1) family of cytokines comprises 11 mem...
updateTrackers	[UpdateTracker:9782310] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v59:[addHasEvent, updateContainedPathway, updateContainedRLE] [UpdateTracker:9781762] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v60:[addHasEvent, updateContainedPathway] [UpdateTracker:9778251] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v68:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9775584] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v78:[updateIndirectRLE] [UpdateTracker:9780729] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v62:[addHasEvent, addLiteratureReference, modifyText, updateContainedRLE] [UpdateTracker:9789053] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v39:[updateContainedRLE] [UpdateTracker:9789798] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v37:[updateContainedRLE] [UpdateTracker:9776403] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v76:[updateIndirectRLE] [UpdateTracker:9784403] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v54:[add_removeHasEvent] [UpdateTracker:9777568] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v70:[updateIndirectRLE] [UpdateTracker:9784614] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v53:[updateContainedRLE] [UpdateTracker:9789916] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v36:[updateContainedRLE] [UpdateTracker:9785940] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v50:[updateContainedRLE] [UpdateTracker:9774706] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v81:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9788704] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v41:[updateContainedRLE] [UpdateTracker:9788208] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v43:[updateContainedRLE] [UpdateTracker:9774959] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v80:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9790250] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v34:[updateContainedRLE] [UpdateTracker:9780003] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v64:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9790080] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v35:[updateContainedRLE] [UpdateTracker:9776798] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v74:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9780168] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v63:[addLiteratureReference, add_removeHasEvent, add_removeSummation, updateContainedPathway, updateIndirectRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-449147] Signaling by Interleukins
(hasEncapsulatedEvent)	[Pathway:R-HSA-2559582] Senescence-Associated Secretory Phenotype (SASP) [Pathway:R-HSA-5620971] Pyroptosis
(updatedInstance)	[UpdateTracker:9782310] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v59:[addHasEvent, updateContainedPathway, updateContainedRLE] [UpdateTracker:9781762] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v60:[addHasEvent, updateContainedPathway] [UpdateTracker:9778251] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v68:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9775584] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v78:[updateIndirectRLE] [UpdateTracker:9780729] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v62:[addHasEvent, addLiteratureReference, modifyText, updateContainedRLE] [UpdateTracker:9789053] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v39:[updateContainedRLE] [UpdateTracker:9789798] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v37:[updateContainedRLE] [UpdateTracker:9776403] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v76:[updateIndirectRLE] [UpdateTracker:9784403] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v54:[add_removeHasEvent] [UpdateTracker:9777568] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v70:[updateIndirectRLE] [UpdateTracker:9784614] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v53:[updateContainedRLE] [UpdateTracker:9789916] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v36:[updateContainedRLE] [UpdateTracker:9785940] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v50:[updateContainedRLE] [UpdateTracker:9774706] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v81:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9788704] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v41:[updateContainedRLE] [UpdateTracker:9788208] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v43:[updateContainedRLE] [UpdateTracker:9774959] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v80:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9790250] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v34:[updateContainedRLE] [UpdateTracker:9780003] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v64:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9790080] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v35:[updateContainedRLE] [UpdateTracker:9776798] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v74:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9780168] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v63:[addLiteratureReference, add_removeHasEvent, add_removeSummation, updateContainedPathway, updateIndirectRLE]

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