Reactome | MYLK (MLCK) Active Calmodulin Binding

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MYLK (MLCK) Active Calmodulin Binding Show undefined attributes

authored	[InstanceEdit:390573] Gillespie, ME, 2009-02-10 05:04:11
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:445777] Gillespie, ME, 2009-11-05
dbId	445797
displayName	MYLK (MLCK) Active Calmodulin Binding
edited	[InstanceEdit:446860] Gillespie, ME, 2009-11-18 [InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
eventOf	[Pathway:R-HSA-445355] Smooth Muscle Contraction - Homo sapiens
followingEvent	[Reaction:R-HSA-445813] Phosphorylation of Smooth Muscle Myosin Light Chains - Homo sapiens [Reaction:R-HSA-5668978] MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex - Homo sapiens
input	[Complex:R-HSA-74294] CALM1:4xCa2+ [cytosol] [EntityWithAccessionedSequence:R-HSA-445807] MYLK(1-1914) [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:445772] Smooth muscle contraction and relaxation [LiteratureReference:5668982] Human platelet myosin light chain kinase requires the calcium-binding protein calmodulin for activity
maxDepth	1
modified	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
name	MYLK (MLCK) Active Calmodulin Binding
orthologousEvent	[Reaction:R-BTA-445797] MYLK (MLCK) Active Calmodulin Binding - Bos taurus [Reaction:R-CFA-445797] MYLK (MLCK) Active Calmodulin Binding - Canis familiaris [Reaction:R-RNO-445797] MYLK (MLCK) Active Calmodulin Binding - Rattus norvegicus [Reaction:R-MMU-445797] MYLK (MLCK) Active Calmodulin Binding - Mus musculus
output	[Complex:R-HSA-445764] MYLK:Ca2+:CALM1 [cytosol]
precedingEvent	[Reaction:R-HSA-74448] Calcium binds calmodulin - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-8981995] Negative regulation by 'p-S,T-PAK1,2 [cytosol]'
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:165091] Rush, MG, 2008-01-11 00:00:00 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-445797
summation	[Summation:445816] Once calcium influx occurs, calmodulin is activated by the b...
updateTrackers	[UpdateTracker:9780981] Update Tracker - [Reaction:445797] MYLK (MLCK) Active Calmodulin Binding - v61:[addRegulator] [UpdateTracker:9785479] Update Tracker - [Reaction:445797] MYLK (MLCK) Active Calmodulin Binding - v52:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9780981] Update Tracker - [Reaction:445797] MYLK (MLCK) Active Calmodulin Binding - v61:[addRegulator] [UpdateTracker:9785479] Update Tracker - [Reaction:445797] MYLK (MLCK) Active Calmodulin Binding - v52:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-445355] Smooth Muscle Contraction [Pathway:R-HSA-5627123] RHO GTPases activate PAKs
(precedingEvent)	[Reaction:R-HSA-445813] Phosphorylation of Smooth Muscle Myosin Light Chains [Reaction:R-HSA-5668978] MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex