MYLK (MLCK) Active Calmodulin Binding

Stable Identifier
R-HSA-445797
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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MYLK (MLCK) Active Calmodulin Binding
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Once calcium influx occurs, calmodulin is activated by the binding of calcium. The active calmodulin complex binds and activates the smooth muscle myosin light chain kinase (Hathaway and Adelstein 1979, Webb 2003).
Literature References
PubMed ID Title Journal Year
14627618 Smooth muscle contraction and relaxation

Webb, RC

Adv Physiol Educ 2003
156362 Human platelet myosin light chain kinase requires the calcium-binding protein calmodulin for activity

Hathaway, DR, Adelstein, RS

Proc. Natl. Acad. Sci. U.S.A. 1979
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
p-S,T-PAK1,2 [cytosol] (Homo sapiens)
Active Unit
p-S,T-PAK1,2 [cytosol]
Orthologous Events
MYLK (MLCK) Active Calmodulin Binding (Bos taurus)
MYLK (MLCK) Active Calmodulin Binding (Canis familiaris)
MYLK (MLCK) Active Calmodulin Binding (Gallus gallus)
MYLK (MLCK) Active Calmodulin Binding (Mus musculus)
MYLK (MLCK) Active Calmodulin Binding (Rattus norvegicus)
MYLK (MLCK) Active Calmodulin Binding (Sus scrofa)
Authored
Gillespie, ME  (2009-02-10)
Reviewed
Rivero Crespo, F  (2014-12-26)
Rush, MG  (2008-01-11)
Created
Gillespie, ME  (2009-11-06)
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