Reactome | SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol

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SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol Show undefined attributes

authored	[InstanceEdit:444041] Jassal, Bijay, 2009-10-20
catalystActivity	[CatalystActivity:444021] serotonin:sodium:chloride symporter activity of SLC6A4 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region [Compartment:70101] cytosol
created	[InstanceEdit:444041] Jassal, Bijay, 2009-10-20
crossReference	[DatabaseIdentifier:12668313] RHEA:51196
dbId	444008
displayName	SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol
edited	[InstanceEdit:8863355] Jassal, Bijay, 2016-03-07
eventOf	[Pathway:R-HSA-380615] Serotonin clearance from the synaptic cleft - Homo sapiens
followingEvent	[Reaction:R-HSA-141186] MAOA:FAD oxidatively deaminates of 5HT - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:172102] serotonin uptake
input	[SimpleEntity:R-ALL-114523] 5HT [extracellular region] [SimpleEntity:R-ALL-188972] Cl- [extracellular region] [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:444030] Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization [LiteratureReference:8863363] Plasma serotonin levels and the platelet serotonin transporter [LiteratureReference:380897] Long story short: the serotonin transporter in emotion regulation and social cognition
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol SERT mediates serotonin uptake
orthologousEvent	[Reaction:R-PFA-444008] SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol - Plasmodium falciparum [Reaction:R-CEL-444008] SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol - Caenorhabditis elegans [Reaction:R-DME-444008] SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol - Drosophila melanogaster [Reaction:R-GGA-444008] SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol - Gallus gallus [Reaction:R-XTR-444008] SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol - Xenopus tropicalis [Reaction:R-DRE-444008] SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol - Danio rerio [Reaction:R-SSC-444008] SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol - Sus scrofa [Reaction:R-BTA-444008] SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol - Bos taurus [Reaction:R-CFA-444008] SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol - Canis familiaris [Reaction:R-RNO-444008] SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol - Rattus norvegicus [Reaction:R-MMU-444008] SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol - Mus musculus
output	[SimpleEntity:R-ALL-209914] 5HT [cytosol] [SimpleEntity:R-ALL-352022] Cl- [cytosol] [SimpleEntity:R-ALL-83910] Na+ [cytosol]
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8863486] Huertas, Jan, 2016-03-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-444008
summation	[Summation:443995] Serotonin (5HT) is a monoamine neurotransmitter. It's cleara...

Referrals

(hasEvent)	[Pathway:R-HSA-380615] Serotonin clearance from the synaptic cleft
(precedingEvent)	[Reaction:R-HSA-141186] MAOA:FAD oxidatively deaminates of 5HT