Reactome | PARVB/Affixin interacts with alpha PIX

Schema > Reaction > Entries

PARVB/Affixin interacts with alpha PIX Show undefined attributes

authored	[InstanceEdit:446002] Matthews, L, 2009-10-12
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:432931] Matthews, L, 2009-08-18
dbId	432946
displayName	PARVB/Affixin interacts with alpha PIX
edited	[InstanceEdit:446331] Matthews, L, 2009-11-12
eventOf	[Pathway:R-HSA-446388] Regulation of cytoskeletal remodeling and cell spreading by IPP complex components - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-195017] ARHGEF6 [cytosol] [EntityWithAccessionedSequence:R-HSA-446016] PARVB [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:446300] Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling [LiteratureReference:432927] The first CH domain of affixin activates Cdc42 and Rac1 through alphaPIX, a Cdc42/Rac1-specific guanine nucleotide exchanging factor
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PARVB/Affixin interacts with alpha PIX
orthologousEvent	[Reaction:R-SSC-432946] PARVB/Affixin interacts with alpha PIX - Sus scrofa [Reaction:R-CEL-432946] PARVB/Affixin interacts with alpha PIX - Caenorhabditis elegans [Reaction:R-DME-432946] PARVB/Affixin interacts with alpha PIX - Drosophila melanogaster [Reaction:R-GGA-432946] PARVB/Affixin interacts with alpha PIX - Gallus gallus [Reaction:R-XTR-432946] PARVB/Affixin interacts with alpha PIX - Xenopus tropicalis [Reaction:R-BTA-432946] PARVB/Affixin interacts with alpha PIX - Bos taurus [Reaction:R-CFA-432946] PARVB/Affixin interacts with alpha PIX - Canis familiaris [Reaction:R-RNO-432946] PARVB/Affixin interacts with alpha PIX - Rattus norvegicus [Reaction:R-MMU-432946] PARVB/Affixin interacts with alpha PIX - Mus musculus
output	[Complex:R-HSA-446035] ParvB/Affixin:Alpha-Pix [cytosol]
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:446332] Wu, C, 2009-11-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-432946
summation	[Summation:432934] The Rho GTPases, Cdc42 and Rac1, play critical roles in cell...

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(hasEvent)

[Pathway:R-HSA-446388] Regulation of cytoskeletal remodeling and cell spreading by IPP complex components