Reactome | PARVB/Affixin interacts with alpha PIX

PARVB/Affixin interacts with alpha PIX

Stable Identifier

R-HSA-432946

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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The Rho GTPases, Cdc42 and Rac1, play critical roles in cell migration by integrating cell-substrate adhesion and actin polymerization. PARVB/affixin appears to participate in the activation of Rac and Cdc42 by associating with alpha PIX through its CH1 domain (Mishima et al., 2004; Rosenberger et al., 2005). This activity of PARVB/affixin could promote the polymerization of actin through the activation of downstream effectors of Rac1/Cdc42, including WASP-Arp2/3 and Mena/VASP. Alpha-PIX, ILK and PARVB can be found at the leading edge of spreading cells (Rosenberger et al., 2005 ), and it is likely that activation of Rac1 and Cdc42 at the lamellipodia in some cells is stimulated by interactions of aPIX with PARVB and regulated by interaction of ILK and PARVB (see Sepulveda and Wu, 2005 ).

Literature References

PubMed ID	Title	Journal	Year
12499396	Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling Rosenberger, G, Jantke, I, Gal, A, Kutsche, K	Hum Mol Genet	2003
15005707	The first CH domain of affixin activates Cdc42 and Rac1 through alphaPIX, a Cdc42/Rac1-specific guanine nucleotide exchanging factor Mishima, W, Suzuki, A, Yamaji, S, Yoshimi, R, Ueda, A, Kaneko, T, Tanaka, J, Miwa, Y, Ohno, S, Ishigatsubo, Y	Genes Cells	2004