PARVB/Affixin interacts with alpha PIX

Stable Identifier
R-HSA-432946
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

The Rho GTPases, Cdc42 and Rac1, play critical roles in cell migration by integrating cell-substrate adhesion and actin polymerization. PARVB/affixin appears to participate in the activation of Rac and Cdc42 by associating with alpha PIX through its CH1 domain (Mishima et al., 2004; Rosenberger et al., 2005). This activity of PARVB/affixin could promote the polymerization of actin through the activation of downstream effectors of Rac1/Cdc42, including WASP-Arp2/3 and Mena/VASP. Alpha-PIX, ILK and PARVB can be found at the leading edge of spreading cells (Rosenberger et al., 2005 ), and it is likely that activation of Rac1 and Cdc42 at the lamellipodia in some cells is stimulated by interactions of aPIX with PARVB and regulated by interaction of ILK and PARVB (see Sepulveda and Wu, 2005 ).

Literature References
PubMed ID Title Journal Year
15005707 The first CH domain of affixin activates Cdc42 and Rac1 through alphaPIX, a Cdc42/Rac1-specific guanine nucleotide exchanging factor

Mishima, W, Suzuki, A, Yamaji, S, Yoshimi, R, Ueda, A, Kaneko, T, Tanaka, J, Miwa, Y, Ohno, S, Ishigatsubo, Y

Genes Cells 2004
12499396 Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling

Rosenberger, G, Jantke, I, Gal, A, Kutsche, K

Hum Mol Genet 2003
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