Reactome | mRNA decay by 3' to 5' exoribonuclease

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mRNA decay by 3' to 5' exoribonuclease Show undefined attributes

authored	[InstanceEdit:430015] May, B, 2009-07-22
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:429836] May, B, 2009-07-23
dbId	429958
displayName	mRNA decay by 3' to 5' exoribonuclease
edited	[InstanceEdit:430015] May, B, 2009-07-22
eventOf	[Pathway:R-HSA-429914] Deadenylation-dependent mRNA decay - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:22759] nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion - Homo sapiens [Reaction:R-HSA-429961] DCPS scavenges the 7-methylguanosine cap of mRNA - Homo sapiens [Reaction:R-HSA-5694126] NT5C3B hydrolyses 7MGP to 7MG - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2016-12-21
literatureReference	[LiteratureReference:429957] The highways and byways of mRNA decay [LiteratureReference:429946] Messenger RNA decay in mammalian cells: the exonuclease perspective [LiteratureReference:429954] The many pathways of RNA degradation [LiteratureReference:430040] From birth to death: the complex lives of eukaryotic mRNAs [LiteratureReference:429833] The enzymes and control of eukaryotic mRNA turnover [LiteratureReference:430007] The cap-to-tail guide to mRNA turnover
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	mRNA decay by 3' to 5' exoribonuclease
orthologousEvent	[Pathway:R-SCE-429958] mRNA decay by 3' to 5' exoribonuclease - Saccharomyces cerevisiae [Pathway:R-SPO-429958] mRNA decay by 3' to 5' exoribonuclease - Schizosaccharomyces pombe [Pathway:R-DDI-429958] mRNA decay by 3' to 5' exoribonuclease - Dictyostelium discoideum [Pathway:R-CEL-429958] mRNA decay by 3' to 5' exoribonuclease - Caenorhabditis elegans [Pathway:R-DME-429958] mRNA decay by 3' to 5' exoribonuclease - Drosophila melanogaster [Pathway:R-GGA-429958] mRNA decay by 3' to 5' exoribonuclease - Gallus gallus [Pathway:R-XTR-429958] mRNA decay by 3' to 5' exoribonuclease - Xenopus tropicalis [Pathway:R-DRE-429958] mRNA decay by 3' to 5' exoribonuclease - Danio rerio [Pathway:R-SSC-429958] mRNA decay by 3' to 5' exoribonuclease - Sus scrofa [Pathway:R-BTA-429958] mRNA decay by 3' to 5' exoribonuclease - Bos taurus [Pathway:R-CFA-429958] mRNA decay by 3' to 5' exoribonuclease - Canis familiaris [Pathway:R-RNO-429958] mRNA decay by 3' to 5' exoribonuclease - Rattus norvegicus [Pathway:R-MMU-429958] mRNA decay by 3' to 5' exoribonuclease - Mus musculus
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:442431] Wilusz, J, 2009-09-17
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-429958
summation	[Summation:429885] The degradation of mRNA from 3' to 5' occurs in two steps. F...
updateTrackers	[UpdateTracker:9784151] Update Tracker - [Pathway:429958] mRNA decay by 3' to 5' exoribonuclease - v54:[addHasEvent] [UpdateTracker:9782416] Update Tracker - [Pathway:429958] mRNA decay by 3' to 5' exoribonuclease - v59:[updateContainedRLE] [UpdateTracker:9790170] Update Tracker - [Pathway:429958] mRNA decay by 3' to 5' exoribonuclease - v35:[updateContainedRLE] [UpdateTracker:9789704] Update Tracker - [Pathway:429958] mRNA decay by 3' to 5' exoribonuclease - v37:[updateContainedRLE]

Referrals

(updatedInstance)

[UpdateTracker:9784151] Update Tracker - [Pathway:429958] mRNA decay by 3' to 5' exoribonuclease - v54:[addHasEvent]
[UpdateTracker:9782416] Update Tracker - [Pathway:429958] mRNA decay by 3' to 5' exoribonuclease - v59:[updateContainedRLE]
[UpdateTracker:9790170] Update Tracker - [Pathway:429958] mRNA decay by 3' to 5' exoribonuclease - v35:[updateContainedRLE]
[UpdateTracker:9789704] Update Tracker - [Pathway:429958] mRNA decay by 3' to 5' exoribonuclease - v37:[updateContainedRLE]

(hasEvent)

[Pathway:R-HSA-429914] Deadenylation-dependent mRNA decay

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