Reactome | SLC2A6,8,10,12 transport Glc from extracellular region to cytosol

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SLC2A6,8,10,12 transport Glc from extracellular region to cytosol Show undefined attributes

authored	[InstanceEdit:429100] Jassal, Bijay, 2009-07-14
catalystActivity	[CatalystActivity:429072] D-glucose transmembrane transporter activity of SLC2A6,8,10,12 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:429100] Jassal, Bijay, 2009-07-14
crossReference	[DatabaseIdentifier:12667692] RHEA:60376
dbId	429094
diseaseReaction	[FailedReaction:R-HSA-5632871] Defective SLC2A10 does not transport Glc from extracellular region to cytosol - Homo sapiens
displayName	SLC2A6,8,10,12 transport Glc from extracellular region to cytosol
edited	[InstanceEdit:429100] Jassal, Bijay, 2009-07-14
eventOf	[Pathway:R-HSA-189200] Cellular hexose transport - Homo sapiens
input	[SimpleEntity:R-ALL-70115] Glc [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:429063] Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes [LiteratureReference:429043] GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity [LiteratureReference:429132] Molecular cloning of a novel member of the GLUT family of transporters, SLC2a10 (GLUT10), localized on chromosome 20q13.1: a candidate gene for NIDDM susceptibility [LiteratureReference:429099] Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome [LiteratureReference:429134] Identification of a novel glucose transporter-like protein-GLUT-12
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	SLC2A6,8,10,12 transport Glc from extracellular region to cytosol Glucose transport by class III GLUTs
negativePrecedingEvent	[NegativePrecedingEvent:9963477] Futile Cycle: GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region [NegativePrecedingEvent:9963473] Futile Cycle: SLC50A1 transports Glc from cytosol to extracellular region
orthologousEvent	[Reaction:R-DDI-429094] SLC2A6,8,10,12 transport Glc from extracellular region to cytosol - Dictyostelium discoideum [Reaction:R-DME-429094] SLC2A6,8,10,12 transport Glc from extracellular region to cytosol - Drosophila melanogaster [Reaction:R-GGA-429094] SLC2A6,8,10,12 transport Glc from extracellular region to cytosol - Gallus gallus [Reaction:R-XTR-429094] SLC2A6,8,10,12 transport Glc from extracellular region to cytosol - Xenopus tropicalis [Reaction:R-DRE-429094] SLC2A6,8,10,12 transport Glc from extracellular region to cytosol - Danio rerio [Reaction:R-SSC-429094] SLC2A6,8,10,12 transport Glc from extracellular region to cytosol - Sus scrofa [Reaction:R-BTA-429094] SLC2A6,8,10,12 transport Glc from extracellular region to cytosol - Bos taurus [Reaction:R-CFA-429094] SLC2A6,8,10,12 transport Glc from extracellular region to cytosol - Canis familiaris [Reaction:R-RNO-429094] SLC2A6,8,10,12 transport Glc from extracellular region to cytosol - Rattus norvegicus [Reaction:R-MMU-429094] SLC2A6,8,10,12 transport Glc from extracellular region to cytosol - Mus musculus
output	[SimpleEntity:R-ALL-70113] Glc [cytosol]
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:433651] He, L, 2009-08-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-429094
summation	[Summation:429142] Class III facilitative transporters consist of five members;...

Referrals

(normalReaction)	[FailedReaction:R-HSA-5632871] Defective SLC2A10 does not transport Glc from extracellular region to cytosol
(hasEvent)	[Pathway:R-HSA-189200] Cellular hexose transport
(precedingEvent)	[NegativePrecedingEvent:9963454] Futile Cycle: SLC2A6,8,10,12 transport Glc from extracellular region to cytosol [NegativePrecedingEvent:9963431] Futile Cycle: SLC2A6,8,10,12 transport Glc from extracellular region to cytosol

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