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PLPP1 dephosphorylates extracellular sphingosine-1-phosphate
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authored
[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
catalystActivity
[CatalystActivity:428666] sphingosine-1-phosphate phosphatase activity of PLPP1 [plasma membrane]
category
transition
compartment
[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created
[InstanceEdit:428672] D'Eustachio, P, 2009-07-06
crossReference
[DatabaseIdentifier:12667862] RHEA:27518
dbId
428690
displayName
PLPP1 dephosphorylates extracellular sphingosine-1-phosphate
edited
[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
eventOf
[Pathway:R-HSA-9845614] Sphingolipid catabolism - Homo sapiens
input
[SimpleEntity:R-ALL-419305] C18-S1P [extracellular region]
[SimpleEntity:R-ALL-109276] H2O [extracellular region]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:200173] Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform.
[LiteratureReference:9844338] Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1
[LiteratureReference:9844350] Lipid phosphate phosphatases and their roles in mammalian physiology and pathology
maxDepth
1
modified
[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name
PLPP1 dephosphorylates extracellular sphingosine-1-phosphate
sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]
orthologousEvent
[Reaction:R-SCE-428690] PLPP1 dephosphorylates extracellular sphingosine-1-phosphate - Saccharomyces cerevisiae
[Reaction:R-SPO-428690] PLPP1 dephosphorylates extracellular sphingosine-1-phosphate - Schizosaccharomyces pombe
[Reaction:R-DDI-428690] PLPP1 dephosphorylates extracellular sphingosine-1-phosphate - Dictyostelium discoideum
[Reaction:R-CEL-428690] PLPP1 dephosphorylates extracellular sphingosine-1-phosphate - Caenorhabditis elegans
[Reaction:R-DME-428690] PLPP1 dephosphorylates extracellular sphingosine-1-phosphate - Drosophila melanogaster
[Reaction:R-GGA-428690] PLPP1 dephosphorylates extracellular sphingosine-1-phosphate - Gallus gallus
[Reaction:R-XTR-428690] PLPP1 dephosphorylates extracellular sphingosine-1-phosphate - Xenopus tropicalis
[Reaction:R-DRE-428690] PLPP1 dephosphorylates extracellular sphingosine-1-phosphate - Danio rerio
[Reaction:R-SSC-428690] PLPP1 dephosphorylates extracellular sphingosine-1-phosphate - Sus scrofa
[Reaction:R-BTA-428690] PLPP1 dephosphorylates extracellular sphingosine-1-phosphate - Bos taurus
[Reaction:R-CFA-428690] PLPP1 dephosphorylates extracellular sphingosine-1-phosphate - Canis familiaris
[Reaction:R-RNO-428690] PLPP1 dephosphorylates extracellular sphingosine-1-phosphate - Rattus norvegicus
[Reaction:R-MMU-428690] PLPP1 dephosphorylates extracellular sphingosine-1-phosphate - Mus musculus
output
[SimpleEntity:R-ALL-109277] Pi [extracellular region]
[SimpleEntity:R-ALL-1132148] sphingosine [cytoplasm]
precedingEvent
[Reaction:R-HSA-9695890] SPNS2,MFSD2B transport S1P from cytosol to extracellular region - Homo sapiens
[Reaction:R-HSA-9843721] ABCC1,ABCG2 transport C18-S1P to extracellular region - Homo sapiens
releaseDate
2009-09-30
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:446905] Hannun, YA, Luberto, C, 2009-11-18
[InstanceEdit:433039] Jassal, B, 2009-08-20
[InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-428690
summation
[Summation:428695] Phospholipid phosphatase 2 (PLPP2, PPAP2A, LPP3) enzyme asso...
updateTrackers
[UpdateTracker:9853236] Update Tracker - [Reaction:428690] PLPP1 dephosphorylates extracellular sphingosine-1-phosphate - v87:[addLiteratureReference, add_removeOutput, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9853236] Update Tracker - [Reaction:428690] PLPP1 dephosphorylates extracellular sphingosine-1-phosphate - v87:[addLiteratureReference, add_removeOutput, modifyText]
(hasEvent)
[Pathway:R-HSA-9845614] Sphingolipid catabolism
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