Reactome | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression

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ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Show undefined attributes

authored	[InstanceEdit:427423] May, B, 2009-06-21
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:427372] May, B, 2009-06-19
dbId	427389
displayName	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
doi	10.3180/r-hsa-427389.1
edited	[InstanceEdit:427423] May, B, 2009-06-21
eventOf	[Pathway:R-HSA-5250913] Positive epigenetic regulation of rRNA expression - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:24868] transcription initiation-coupled chromatin remodeling
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-74987] TTF-I binds to the Sal Box - Homo sapiens [Reaction:R-HSA-427404] Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene - Homo sapiens [Reaction:R-HSA-427336] TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9 - Homo sapiens [Reaction:R-HSA-427383] CBX3 (HP1gamma) binds histone H3 dimethylated at lysine-9 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:427448] Activation of RNA polymerase I transcription by cockayne syndrome group B protein and histone methyltransferase G9a [LiteratureReference:427414] Structure and function of ribosomal RNA gene chromatin [LiteratureReference:5096457] Epigenetic control of RNA polymerase I transcription in mammalian cells [LiteratureReference:5219091] Basic mechanisms in RNA polymerase I transcription of the ribosomal RNA genes [LiteratureReference:5250510] Structure and epigenetics of nucleoli in comparison with non-nucleolar compartments [LiteratureReference:5365878] Dysregulation of RNA polymerase I transcription during disease [LiteratureReference:5368160] Chromatin organization of active ribosomal RNA genes
maxDepth	2
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Activation of rRNA Expression by ERCC6 (CSB) and EHMT2 (G9a) Activation of rRNA Expression by Cockayne Syndrome Protein CSB and Histone Methyltransferase G9a
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8856904] Iben, Sebastian, 2016-02-12
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-427389
summation	[Summation:427443] About half of the rRNA genes in the genome are actively expr...

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[Pathway:R-HSA-5250913] Positive epigenetic regulation of rRNA expression

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