Reactome | Endonucleolytic RISC hydrolyzes target RNAs

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Endonucleolytic RISC hydrolyzes target RNAs Show undefined attributes

authored	[InstanceEdit:426442] May, B, 2009-06-10
catalystActivity	[CatalystActivity:426499] RNA endonuclease activity of Endonucleolytic RISC [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:426518] May, B, 2009-06-16
dbId	426520
displayName	Endonucleolytic RISC hydrolyzes target RNAs
edited	[InstanceEdit:426442] May, B, 2009-06-10
eventOf	[Pathway:R-HSA-426496] Post-transcriptional silencing by small RNAs - Homo sapiens
input	[OtherEntity:R-ALL-426523] RNA (exact match) [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:426507] Molecular basis for target RNA recognition and cleavage by human RISC [LiteratureReference:426516] A microRNA in a multiple-turnover RNAi enzyme complex [LiteratureReference:426506] Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs [LiteratureReference:210573] Argonaute2 is the catalytic engine of mammalian RNAi [LiteratureReference:427766] Functional Dissection of Human TNRC6, GW182-related, Family of proteins [LiteratureReference:427785] Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs [LiteratureReference:427826] Identification of novel argonaute-associated proteins [LiteratureReference:432337] Purified Argonaute2 and an siRNA form recombinant human RISC [LiteratureReference:6789369] Human Argonaute 2 Has Diverse Reaction Pathways on Target RNAs
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	Endonucleolytic RISC hydrolyzes target RNAs
orthologousEvent	[Reaction:R-SSC-426520] Endonucleolytic RISC hydrolyzes target RNAs - Sus scrofa [Reaction:R-SPO-426520] Endonucleolytic RISC hydrolyzes target RNAs - Schizosaccharomyces pombe [Reaction:R-CEL-426520] Endonucleolytic RISC hydrolyzes target RNAs - Caenorhabditis elegans [Reaction:R-DME-426520] Endonucleolytic RISC hydrolyzes target RNAs - Drosophila melanogaster [Reaction:R-GGA-426520] Endonucleolytic RISC hydrolyzes target RNAs - Gallus gallus [Reaction:R-XTR-426520] Endonucleolytic RISC hydrolyzes target RNAs - Xenopus tropicalis [Reaction:R-BTA-426520] Endonucleolytic RISC hydrolyzes target RNAs - Bos taurus [Reaction:R-CFA-426520] Endonucleolytic RISC hydrolyzes target RNAs - Canis familiaris [Reaction:R-RNO-426520] Endonucleolytic RISC hydrolyzes target RNAs - Rattus norvegicus [Reaction:R-MMU-426520] Endonucleolytic RISC hydrolyzes target RNAs - Mus musculus
output	2 × [OtherEntity:R-ALL-426511] Cleaved RNA with 5' Phosphate and 3' Hydroxyl [cytosol]
precedingEvent	[Reaction:R-HSA-9023909] C3PO hydrolyzes cleaved passenger strand - Homo sapiens
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2106616] Tomari, Y, 2012-02-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-426520
summation	[Summation:426491] Human Argonaute-2 (AGO2, EIF2C2) possesses ribonucleolytic a...
updateTrackers	[UpdateTracker:9787435] Update Tracker - [Reaction:426520] Endonucleolytic RISC hydrolyzes target RNAs - v45:[modifyText] [UpdateTracker:9784443] Update Tracker - [Reaction:426520] Endonucleolytic RISC hydrolyzes target RNAs - v54:[addLiteratureReference] [UpdateTracker:9787207] Update Tracker - [Reaction:426520] Endonucleolytic RISC hydrolyzes target RNAs - v46:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9787435] Update Tracker - [Reaction:426520] Endonucleolytic RISC hydrolyzes target RNAs - v45:[modifyText] [UpdateTracker:9784443] Update Tracker - [Reaction:426520] Endonucleolytic RISC hydrolyzes target RNAs - v54:[addLiteratureReference] [UpdateTracker:9787207] Update Tracker - [Reaction:426520] Endonucleolytic RISC hydrolyzes target RNAs - v46:[modifyText]
(hasEvent)	[Pathway:R-HSA-426496] Post-transcriptional silencing by small RNAs

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