Reactome | SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region

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SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region Show undefined attributes

authored	[InstanceEdit:426114] Jassal, Bijay, 2009-06-12
catalystActivity	[CatalystActivity:426138] potassium:chloride symporter activity of SLC12A4,5,6,7 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:426114] Jassal, Bijay, 2009-06-12
crossReference	[DatabaseIdentifier:12668159] RHEA:72427 [DatabaseIdentifier:9959216] RHEA:72428
dbId	426155
diseaseReaction	[FailedReaction:R-HSA-5623806] Defective SLC12A6 does not cotransport K+, Cl- from cytosol to extracellular region - Homo sapiens
displayName	SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region
edited	[InstanceEdit:426114] Jassal, Bijay, 2009-06-12
eventOf	[Pathway:R-HSA-426117] Cation-coupled Chloride cotransporters - Homo sapiens
input	[SimpleEntity:R-ALL-352022] Cl- [cytosol] [SimpleEntity:R-ALL-29804] K+ [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:426137] Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family [LiteratureReference:426145] Molecular, functional, and genomic characterization of human KCC2, the neuronal K-Cl cotransporter [LiteratureReference:426112] Molecular cloning and functional characterization of KCC3, a new K-Cl cotransporter [LiteratureReference:426162] The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum [LiteratureReference:426152] Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region K+/Cl- cotransport
negativePrecedingEvent	[NegativePrecedingEvent:9963187] Futile Cycle: SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol
orthologousEvent	[Reaction:R-CEL-426155] SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region - Caenorhabditis elegans [Reaction:R-DME-426155] SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region - Drosophila melanogaster [Reaction:R-GGA-426155] SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region - Gallus gallus [Reaction:R-XTR-426155] SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region - Xenopus tropicalis [Reaction:R-DRE-426155] SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region - Danio rerio [Reaction:R-SSC-426155] SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region - Sus scrofa [Reaction:R-BTA-426155] SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region - Bos taurus [Reaction:R-CFA-426155] SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region - Canis familiaris [Reaction:R-RNO-426155] SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region - Rattus norvegicus [Reaction:R-MMU-426155] SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region - Mus musculus
output	[SimpleEntity:R-ALL-188972] Cl- [extracellular region] [SimpleEntity:R-ALL-74126] K+ [extracellular region]
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:433651] He, L, 2009-08-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-426155
summation	[Summation:426080] K+/Cl- cotransport is implicated not only in regulatory volu...
updateTrackers	[UpdateTracker:9789431] Update Tracker - [Reaction:426155] SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region - v38:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9789431] Update Tracker - [Reaction:426155] SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region - v38:[modifyText]
(normalReaction)	[FailedReaction:R-HSA-5623806] Defective SLC12A6 does not cotransport K+, Cl- from cytosol to extracellular region
(hasEvent)	[Pathway:R-HSA-426117] Cation-coupled Chloride cotransporters
(precedingEvent)	[NegativePrecedingEvent:9963172] Futile Cycle: SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region

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