Reactome | Na+-driven Cl-/HCO3- exchanger transport

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Na+-driven Cl-/HCO3- exchanger transport Show undefined attributes

authored	[InstanceEdit:425571] Jassal, Bijay, 2009-06-05
catalystActivity	[CatalystActivity:425598] solute:inorganic anion antiporter activity of Na+-driven Cl-/HCO3- exchanger proteins [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:425571] Jassal, Bijay, 2009-06-05
dbId	425577
displayName	Na+-driven Cl-/HCO3- exchanger transport
edited	[InstanceEdit:425571] Jassal, Bijay, 2009-06-05
eventOf	[Pathway:R-HSA-425381] Bicarbonate transporters - Homo sapiens
followingEvent	[Reaction:R-HSA-425482] SLC4A1,2,3 exchanges HCO3- for Cl- - Homo sapiens [Reaction:R-HSA-427555] SLC26A1,2 cotransport SO4(2-), anion from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-425483] SLC4A5,7,9 cotransport Na+ with 3HCO3- - Homo sapiens [Reaction:R-HSA-8878664] SLC4A4 cotransports Na+ with 3HCO3- - Homo sapiens [Reaction:R-HSA-427666] SLC26A3,6 exchange Cl- for HCO3- - Homo sapiens
input	[SimpleEntity:R-ALL-352022] Cl- [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-425425] HCO3- [extracellular region] [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:425596] Characterization of human SLC4A10 as an electroneutral Na/HCO3 cotransporter (NBCn2) with Cl- self-exchange activity [LiteratureReference:425559] Characterization of Na+/HCO-3 cotransporter isoform NBC-3
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Na+-driven Cl-/HCO3- exchanger transport
orthologousEvent	[Reaction:R-MMU-425577] Na+-driven Cl-/HCO3- exchanger transport - Mus musculus [Reaction:R-RNO-425577] Na+-driven Cl-/HCO3- exchanger transport - Rattus norvegicus [Reaction:R-CFA-425577] Na+-driven Cl-/HCO3- exchanger transport - Canis familiaris [Reaction:R-BTA-425577] Na+-driven Cl-/HCO3- exchanger transport - Bos taurus [Reaction:R-CEL-425577] Na+-driven Cl-/HCO3- exchanger transport - Caenorhabditis elegans [Reaction:R-DME-425577] Na+-driven Cl-/HCO3- exchanger transport - Drosophila melanogaster [Reaction:R-GGA-425577] Na+-driven Cl-/HCO3- exchanger transport - Gallus gallus [Reaction:R-XTR-425577] Na+-driven Cl-/HCO3- exchanger transport - Xenopus tropicalis [Reaction:R-DRE-425577] Na+-driven Cl-/HCO3- exchanger transport - Danio rerio [Reaction:R-SSC-425577] Na+-driven Cl-/HCO3- exchanger transport - Sus scrofa
output	[SimpleEntity:R-ALL-188972] Cl- [extracellular region] [SimpleEntity:R-ALL-351626] H+ [extracellular region] [SimpleEntity:R-ALL-111627] HCO3- [cytosol] [SimpleEntity:R-ALL-83910] Na+ [cytosol]
precedingEvent	[Reaction:R-HSA-425482] SLC4A1,2,3 exchanges HCO3- for Cl- - Homo sapiens [Reaction:R-HSA-427555] SLC26A1,2 cotransport SO4(2-), anion from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-425483] SLC4A5,7,9 cotransport Na+ with 3HCO3- - Homo sapiens [Reaction:R-HSA-8878664] SLC4A4 cotransports Na+ with 3HCO3- - Homo sapiens [Reaction:R-HSA-427666] SLC26A3,6 exchange Cl- for HCO3- - Homo sapiens
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:433651] He, L, 2009-08-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-425577
summation	[Summation:425565] Two genes encode Na+-dependent Cl-/HCO3- exchangers; SLC4A8 ...

Referrals

(hasEvent)	[Pathway:R-HSA-425381] Bicarbonate transporters
(precedingEvent)	[Reaction:R-HSA-425482] SLC4A1,2,3 exchanges HCO3- for Cl- [Reaction:R-HSA-427555] SLC26A1,2 cotransport SO4(2-), anion from extracellular region to cytosol [Reaction:R-HSA-425483] SLC4A5,7,9 cotransport Na+ with 3HCO3- [Reaction:R-HSA-8878664] SLC4A4 cotransports Na+ with 3HCO3- [Reaction:R-HSA-427666] SLC26A3,6 exchange Cl- for HCO3-

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