Reactome | Na+-driven Cl-/HCO3- exchanger transport

Na+-driven Cl-/HCO3- exchanger transport

Stable Identifier

R-HSA-425577

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Na+-driven Cl-/HCO3- exchanger transport

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Two genes encode Na+-dependent Cl-/HCO3- exchangers; SLC4A8 (NDCBE1) and 10 (NCBE). SLC4A8 (NDCBE1) encodes a exchanger protein which mediates Na+:HCO3- transport with a stoichiometry of 1:2:1 (Na+/HCO3-/Cl-). This protein is highly expressed in brain and spine and moderately expressed in trachea, thyroid, and kidney (Amlal H et al, 1999). SLC4A10 (NCBE, NBCn2) encodes a Na+-driven Cl-/HCO3- exchanger protein (Parker MD et al, 2008). It transports extracellular Na+ and HCO3- into cells in exchange for intracellular Cl- and H+, thus raising the intracellular pH.

Literature References

PubMed ID	Title	Journal	Year
18319254	Characterization of human SLC4A10 as an electroneutral Na/HCO3 cotransporter (NBCn2) with Cl- self-exchange activity Parker, MD, Musa-Aziz, R, Rojas, JD, Choi, I, Daly, CM, Boron, WF	J Biol Chem	2008
10362779	Characterization of Na+/HCO-3 cotransporter isoform NBC-3 Amlal, H, Burnham, CE, Soleimani, M	Am J Physiol	1999