Na+-driven Cl-/HCO3- exchanger transport

Stable Identifier
Reaction [transition]
Homo sapiens
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Two genes encode Na+-dependent Cl-/HCO3- exchangers; SLC4A8 (NDCBE1) and 10 (NCBE). SLC4A8 (NDCBE1) encodes a exchanger protein which mediates Na+:HCO3- transport with a stoichiometry of 1:2:1 (Na+/HCO3-/Cl-). This protein is highly expressed in brain and spine and moderately expressed in trachea, thyroid, and kidney (Amlal H et al, 1999). SLC4A10 (NCBE, NBCn2) encodes a Na+-driven Cl-/HCO3- exchanger protein (Parker MD et al, 2008). It transports extracellular Na+ and HCO3- into cells in exchange for intracellular Cl- and H+, thus raising the intracellular pH.

Literature References
PubMed ID Title Journal Year
18319254 Characterization of human SLC4A10 as an electroneutral Na/HCO3 cotransporter (NBCn2) with Cl- self-exchange activity

Choi, I, Daly, CM, Rojas, JD, Parker, MD, Boron, WF, Musa-Aziz, R

J Biol Chem 2008
10362779 Characterization of Na+/HCO-3 cotransporter isoform NBC-3

Soleimani, M, Burnham, CE, Amlal, H

Am J Physiol 1999
Catalyst Activity

inorganic anion exchanger activity of Na+-driven Cl-/HCO3- exchanger proteins [plasma membrane]

Orthologous Events
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