Reactome | PALB2 [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

PALB2 [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-5685655] BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] - Homo sapiens
consumedByEvent	[FailedReaction:R-HSA-9701199] Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding - Homo sapiens [FailedReaction:R-HSA-9709601] Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding - Homo sapiens [Reaction:R-HSA-5693620] D-loop formation mediated by PALB2, BRCA2 and RAD51 - Homo sapiens
created	[InstanceEdit:419550] Matthews, L, 2009-05-02 17:28:34
dbId	419548
displayName	PALB2 [nucleoplasm]
endCoordinate	1186
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-419548] Palb2 [nucleoplasm] - Mus musculus [EntityWithAccessionedSequence:R-RNO-419548] Palb2 [nucleoplasm] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-419548] PALB2 [nucleoplasm] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-419548] PALB2 [nucleoplasm] - Bos taurus [EntityWithAccessionedSequence:R-SSC-419548] PALB2 [nucleoplasm] - Sus scrofa [GenomeEncodedEntity:R-DRE-419548] Ghost homologue of PALB2 [nucleoplasm] - Danio rerio [EntityWithAccessionedSequence:R-XTR-419548] palb2 [nucleoplasm] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-419548] PALB2 [nucleoplasm] - Gallus gallus
maxDepth	1
modified	[InstanceEdit:3448660] Wu, G, 2013-05-16
name	PALB2 Partner and localizer of BRCA2 PALB2_HUMAN
producedByEvent	[BlackBoxEvent:R-HSA-5686483] Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) - Homo sapiens [BlackBoxEvent:R-HSA-5686469] Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 - Homo sapiens [Reaction:R-HSA-5686410] BLM mediates dissolution of double Holliday junction - Homo sapiens [Reaction:R-HSA-5693589] D-loop dissociation and strand annealing - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:Q86YC2] UniProt:Q86YC2 PALB2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-419548
startCoordinate	1
updateTrackers	[UpdateTracker:9880267] Update Tracker - [EntityWithAccessionedSequence:419548] PALB2 [nucleoplasm] - v44:[addEndCoordinate, addStartCoordinate]

Referrals

(updatedInstance)	[UpdateTracker:9880267] Update Tracker - [EntityWithAccessionedSequence:419548] PALB2 [nucleoplasm] - v44:[addEndCoordinate, addStartCoordinate]
(normalEntity)	[EntityFunctionalStatus:9704407] loss_of_function of PALB2 mutants (BRCA1 binding) [nucleoplasm] [EntityFunctionalStatus:9704404] loss_of_function of PALB2 mutants (BRCA2/RAD51/RAD51C binding) [nucleoplasm]
(input)	[FailedReaction:R-HSA-9701199] Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding [FailedReaction:R-HSA-9709601] Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding [Reaction:R-HSA-5693620] D-loop formation mediated by PALB2, BRCA2 and RAD51
(output)	[Reaction:R-HSA-5686410] BLM mediates dissolution of double Holliday junction [BlackBoxEvent:R-HSA-5686483] Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [Reaction:R-HSA-5693589] D-loop dissociation and strand annealing [BlackBoxEvent:R-HSA-5686469] Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
(hasComponent)	[Complex:R-HSA-5685655] BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm]

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