Reactome | EPH receptors autophosphorylate

Schema > Reaction > Entries

EPH receptors autophosphorylate Show undefined attributes

authored	[InstanceEdit:3928653] Garapati, P V, 2013-07-22
catalystActivity	[CatalystActivity:3928629] protein tyrosine kinase activity of EPH-ephrin oligomers [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:3928638] Garapati, P V, 2013-07-22
dbId	3928578
displayName	EPH receptors autophosphorylate
edited	[InstanceEdit:3928653] Garapati, P V, 2013-07-22
eventOf	[Pathway:R-HSA-2682334] EPH-Ephrin signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-4093330] EPHB binds p120-RasGAP - Homo sapiens [Reaction:R-HSA-4093332] p-EPHB phosphorylates SDC2 - Homo sapiens [Reaction:R-HSA-3928617] EPHB2 binds KALRN - Homo sapiens [Reaction:R-HSA-3928644] EPHB binds ITSN1 - Homo sapiens [Reaction:R-HSA-3928584] p-EPHs bind SRC,FYN,YES,LYN - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-HSA-3928372] EPH-ephrin oligomers [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3928237] Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptors
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	EPH receptors autophosphorylate
orthologousEvent	[Reaction:R-CEL-3928578] EPH receptors autophosphorylate - Caenorhabditis elegans [Reaction:R-DME-3928578] EPH receptors autophosphorylate - Drosophila melanogaster [Reaction:R-GGA-3928578] EPH receptors autophosphorylate - Gallus gallus [Reaction:R-XTR-3928578] EPH receptors autophosphorylate - Xenopus tropicalis [Reaction:R-DRE-3928578] EPH receptors autophosphorylate - Danio rerio [Reaction:R-SSC-3928578] EPH receptors autophosphorylate - Sus scrofa [Reaction:R-BTA-3928578] EPH receptors autophosphorylate - Bos taurus [Reaction:R-CFA-3928578] EPH receptors autophosphorylate - Canis familiaris [Reaction:R-RNO-3928578] EPH receptors autophosphorylate - Rattus norvegicus [Reaction:R-MMU-3928578] EPH receptors autophosphorylate - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-HSA-3928351] p-EPH:ephrin oligomers [plasma membrane]
precedingEvent	[Polymerisation:R-HSA-3928591] EPH:EFN tetramers oligomerise - Homo sapiens
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5490284] Ip, Nancy Y, 2014-05-19
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3928578
summation	[Summation:3928294] Following ligand binding, EPH signaling is initiated through...

Referrals

(precedingEvent)	[Reaction:R-HSA-4093330] EPHB binds p120-RasGAP [Reaction:R-HSA-4093332] p-EPHB phosphorylates SDC2 [Reaction:R-HSA-3928617] EPHB2 binds KALRN [Reaction:R-HSA-3928644] EPHB binds ITSN1 [Reaction:R-HSA-3928584] p-EPHs bind SRC,FYN,YES,LYN
(hasEvent)	[Pathway:R-HSA-2682334] EPH-Ephrin signaling