Reactome | glyoxylate + alanine => glycine + pyruvate [peroxisome]

Schema > Reaction > Entries

glyoxylate + alanine => glycine + pyruvate [peroxisome] Show undefined attributes

authored	[InstanceEdit:389673] D'Eustachio, P, 2009-01-11 19:48:01
catalystActivity	[CatalystActivity:389659] alanine-glyoxylate transaminase activity of AGXT dimer [peroxisomal matrix]
category	transition
compartment	[Compartment:17951] peroxisomal matrix
created	[InstanceEdit:389673] D'Eustachio, P, 2009-01-11 19:48:01
crossReference	[DatabaseIdentifier:12667697] RHEA:24249 [DatabaseIdentifier:9930605] RHEA:24249
dbId	389684
displayName	glyoxylate + alanine => glycine + pyruvate [peroxisome]
edited	[InstanceEdit:392437] D'Eustachio, P, 2009-03-03 14:28:53
eventOf	[Pathway:R-HSA-389661] Glyoxylate metabolism and glycine degradation - Homo sapiens
followingEvent	[Reaction:R-HSA-389821] glycine + O2 => glyoxylate + H2O2 + NH4+ - Homo sapiens
input	[SimpleEntity:R-ALL-389678] glyoxylate [peroxisomal matrix] [SimpleEntity:R-ALL-389664] L-Ala [peroxisomal matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:389677] Overexpression of human alanine:glyoxylate aminotransferase in Escherichia coli: renaturation from guanidine-HCl and affinity for pyridoxal phosphate co-factor [LiteratureReference:389668] Further studies on the activity and subcellular distribution of alanine:glyoxylate aminotransferase in the livers of patients with primary hyperoxaluria type 1 [LiteratureReference:389665] Identification of mutations associated with peroxisome-to-mitochondrion mistargeting of alanine/glyoxylate aminotransferase in primary hyperoxaluria type 1 [LiteratureReference:389660] Human peroxisomal L-alanine: glyoxylate aminotransferase. Evolutionary loss of a mitochondrial targeting signal by point mutation of the initiation codon [LiteratureReference:389663] Crystal structure of alanine:glyoxylate aminotransferase and the relationship between genotype and enzymatic phenotype in primary hyperoxaluria type 1
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	glyoxylate + alanine => glycine + pyruvate [peroxisome] glyoxylate + L-alanine => glycine + pyruvate
orthologousEvent	[Reaction:R-DRE-389684] glyoxylate + alanine => glycine + pyruvate [peroxisome] - Danio rerio [Reaction:R-DDI-389684] glyoxylate + alanine => glycine + pyruvate [peroxisome] - Dictyostelium discoideum [Reaction:R-CEL-389684] glyoxylate + alanine => glycine + pyruvate [peroxisome] - Caenorhabditis elegans [Reaction:R-DME-389684] glyoxylate + alanine => glycine + pyruvate [peroxisome] - Drosophila melanogaster [Reaction:R-GGA-389684] glyoxylate + alanine => glycine + pyruvate [peroxisome] - Gallus gallus [Reaction:R-XTR-389684] glyoxylate + alanine => glycine + pyruvate [peroxisome] - Xenopus tropicalis [Reaction:R-SSC-389684] glyoxylate + alanine => glycine + pyruvate [peroxisome] - Sus scrofa [Reaction:R-BTA-389684] glyoxylate + alanine => glycine + pyruvate [peroxisome] - Bos taurus [Reaction:R-CFA-389684] glyoxylate + alanine => glycine + pyruvate [peroxisome] - Canis familiaris [Reaction:R-RNO-389684] glyoxylate + alanine => glycine + pyruvate [peroxisome] - Rattus norvegicus [Reaction:R-MMU-389684] glyoxylate + alanine => glycine + pyruvate [peroxisome] - Mus musculus
output	[SimpleEntity:R-ALL-193446] Gly [peroxisomal matrix] [SimpleEntity:R-ALL-389680] PYR [peroxisomal matrix]
precedingEvent	[Reaction:R-HSA-389821] glycine + O2 => glyoxylate + H2O2 + NH4+ - Homo sapiens [Reaction:R-HSA-389842] HAO1 tetramer oxidizes glycolate to glyoxylate - Homo sapiens [BlackBoxEvent:R-HSA-6784434] An unknown carrier transports cytosolic glyoxylate to the peroxisome - Homo sapiens
releaseDate	2009-04-01
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:392439] Jassal, B, 2009-03-03 14:29:24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-389684
summation	[Summation:389683] Alanine-glyoxylate transaminase (AGXT) catalyzes the irrever...

Referrals

(hasEvent)	[Pathway:R-HSA-389661] Glyoxylate metabolism and glycine degradation
(precedingEvent)	[Reaction:R-HSA-389821] glycine + O2 => glyoxylate + H2O2 + NH4+

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